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unc-13 homolog D

Summary

Gene Symbol

UNC13D

Organism

Homo sapiens (human)

External Links

NCBI Gene

201294

PubChem

201294

Alliance of Genome Resources

HGNC:23147

Annotation

Keyword

Alternative splicing
Calcium
Cytoplasm
Endosome
Exocytosis
Familial hemophagocytic lymphohistiocytosis
Lysosome
Membrane
Metal-binding
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q70J99	Munc13-4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
granuloma formation	IEA
germinal center formation	IEA
regulation of mast cell degranulation	IMP	15548590
defense response to virus	IEA
phagocytosis	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

granuloma formation

leukocyte degranulation [inference]

natural killer cell degranulation

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

germinal center formation

cellular process [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

natural killer cell degranulation

endocytosis [inference]

phagocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

natural killer cell degranulation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

germinal center formation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

germinal center formation

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

natural killer cell degranulation

endocytosis [inference]

phagocytosis

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

natural killer cell degranulation

import into cell [inference]

endocytosis [inference]

phagocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

natural killer cell degranulation

establishment of localization in cell [inference]

leukocyte degranulation [inference]

natural killer cell degranulation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune effector process [inference]

regulation of leukocyte mediated immunity [inference]

regulation of myeloid leukocyte mediated immunity [inference]

regulation of mast cell degranulation

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

positive regulation of regulated secretory pathway

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

positive regulation of regulated secretory pathway

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

regulation of substrate adhesion-dependent cell spreading [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

positive regulation of regulated secretory pathway

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

regulation of mast cell degranulation

positive regulation of regulated secretory pathway

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of regulated secretory pathway

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
Weibel-Palade body	IDA	22899725
lysosome	IDA	15548590
exocytic vesicle	IBA IDA	17237785
cytosol	IDA
azurophil granule lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

transport vesicle [inference]

exocytic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

exocytic vesicle

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

transport vesicle [inference]

exocytic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

exocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

transport vesicle [inference]

exocytic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

exocytic vesicle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15548590 16278825 25312756 26627825 33513601
small GTPase binding	IDA IPI	22899725
metal ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

BAI1-associated protein 3

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
C2 domain superfamily
C2 domain
Mammalian uncoordinated homology 13, domain 2
Munc13 homology 1

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110923	familial hemophagocytic lymphohistiocytosis 3	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 75 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Macaca nemestrina	105469178			MACNE15223
Mandrillus leucophaeus	105528723			MANLE00169
Cercocebus atys	105577716			CERAT23038
Propithecus coquereli	105824717			PROCO09753
Microcebus murinus	105878948			MICMU14340
Dipodomys ordii	106003248			DIPOR04024
Salmo salar	106589471			SALSA99644
Equus asinus asinus	106830307			EQUAS09889
Cyprinodon variegatus	107098151			CYPVA00930
Sinocyclocheilus grahami	107597824			SINGR60672

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Last updated: December 9, 2024