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STT3 oligosaccharyltransferase complex catalytic subunit B

Summary

Gene Symbol

STT3B

Aliases

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
FLJ90106
SIMP
STT3-B
dolichyl-diphosphooligosaccharide protein glycotransferase
source of immunodominant MHC associated peptides

Organism

Homo sapiens (human)

External Links

NCBI Gene

201595

HGNC

30611

KEGG Gene ID

hsa:201595

PubChem

201595

Alliance of Genome Resources

HGNC:30611

Annotation

Keyword

3D-structure
Acetylation
Congenital disorder of glycosylation
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Magnesium
Manganese
Metal-binding
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TCJ2	Source of immunodominant MHC-associated peptides homolog

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
protein N-linked glycosylation	IDA IMP	22467853 31831667
protein N-linked glycosylation via asparagine	IBA IMP ISS	19167329 22607976
ERAD pathway	IMP	22607976
post-translational protein modification	IBA IMP	19167329 22607976
co-translational protein modification	IMP	19167329

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to topologically incorrect protein [inference]

response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to topologically incorrect protein [inference]

response to unfolded protein

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
oligosaccharyltransferase I complex	ISS
endoplasmic reticulum membrane	NAS	31831667
oligosaccharyltransferase complex	IDA IPI TAS	19167329 22467853 22607976 31831667
membrane	HDA	19946888

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase I complex

endoplasmic reticulum protein-containing complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase I complex

catalytic complex [inference]

transferase complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase I complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IBA IMP ISS	19167329 22467853 22607976
metal ion binding	IEA
protein binding	IPI	19167329 30021884 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

oligosaccharyl transferase activity [inference]

dolichyl-diphosphooligosaccharide-protein glycotransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000163527

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K07151

Name

dolichyl-diphosphooligosaccharide---protein glycosyltransferase [EC:2.4.99.18]

References

12887896

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05976	2.4.99.18	G72079JG	G57930PW

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0080572	congenital disorder of glycosylation Iw	Alliance of Genome Resources
DOID:0080573	congenital disorder of glycosylation Ix	DisGeNET Alliance of Genome Resources
DOID:10112	sleeping sickness	DisGeNET
DOID:10113	trypanosomiasis	DisGeNET
DOID:1059	intellectual disability	DisGeNET
DOID:10844	Japanese encephalitis	DisGeNET
DOID:10907	microcephaly	DisGeNET
DOID:11383	cryptorchidism	DisGeNET
DOID:11832	visual epilepsy	DisGeNET
DOID:12205	dengue disease	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000046	Small scrotum
HP:0000054	Micropenis
HP:0000078	Abnormality of the genital system
HP:0000252	Microcephaly
HP:0000648	Optic atrophy
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001252	Hypotonia

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:370924	STT3B-congenital disorder of glycosylation
OMIM:615597	STT3B-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

STT3B-congenital disorder of glycosylation

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ix; CDG1X

KEGG Diseases

Congenital disorders of glycosylation type I

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006028
Gene Name: STT3B, subunit of the oligosaccharyltransferase complex (catalytic)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175886	WB:WBGene00020437
Drosophila melanogaster	43005	FB:FBgn0011336
Callorhinchus milii	103176264		CALMI09700
Latimeria chalumnae	102353150		LATCH05286
Danio rerio	323918	ZFIN:ZDB-GENE-030131-2638
Electrophorus electricus	113583121		ELEEL31406
Esox lucius	105008063		ESOLU27612
Salmo trutta	115173308		SALTR106846
Salmo trutta	115176036		SALTR03889
Gadus morhua	115535710		GADMO34978

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements