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dynein axonemal heavy chain 12

Summary

Gene Symbol

DNAH12

Organism

Homo sapiens (human)

External Links

NCBI Gene

201625

PubChem

201625

Alliance of Genome Resources

HGNC:2943

Annotation

Keyword

ATP-binding
Alternative splicing
Cilium
Coiled coil
Cytoskeleton
Dynein
Microtubule
Motor protein
Proteomics identification
Reference proteome
Repeat
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6ZR08	Axonemal beta dynein heavy chain 12 Axonemal dynein heavy chain 12-like protein Axonemal dynein heavy chain 7-like protein Ciliary dynein heavy chain 12 Dynein axonemal heavy chain 7-like Dynein heavy chain domain-containing protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
microtubule-based movement	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement

Displaying **all 2** entries
GO Term	Evidence Code	PMID
microtubule	IEA
axonemal dynein complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

dynein complex [inference]

axonemal dynein complex

catalytic complex [inference]

dynein complex [inference]

axonemal dynein complex

cellular anatomical entity [inference]

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying **all 5** entries
GO Term	Evidence Code	PMID
minus-end-directed microtubule motor activity	IEA
dynein intermediate chain binding	IEA
ATP hydrolysis activity	IEA
dynein light intermediate chain binding	IEA
ATP binding	IEA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity [inference]

minus-end-directed microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity [inference]

minus-end-directed microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

heavy chain of dynein

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
dynein intermediate chain binding
dynein light intermediate chain binding
microtubule-based movement
minus-end-directed microtubule motor activity

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InterPro
Dynein heavy chain 3, AAA+ lid domain
Dynein heavy chain AAA lid domain superfamily
Dynein heavy chain AAA lid domain
Dynein heavy chain region D6 P-loop domain
Dynein heavy chain, AAA 5 extension domain
Dynein heavy chain, AAA module D4
Dynein heavy chain, AAA1 domain, small subdomain
Dynein heavy chain, ATP-binding dynein motor region
Dynein heavy chain, C-terminal domain
Dynein heavy chain, coiled coil stalk

Ortholog

Displaying entries **1 - 10** of 63 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	38226		FB:FBgn0013811
Mus musculus	110083		MGI:107720	MOUSE12536
Rattus norvegicus	252896		RGD:619990
Rattus norvegicus	252959			RATNO11683
Pan troglodytes	460471	9598_0:001293		PANTR31402
Canis lupus familiaris	484715			CANLF07398
Danio rerio	799461		ZFIN:ZDB-GENE-090311-9	DANRE24167
Equus caballus	100050892			HORSE11471
Ornithorhynchus anatinus	100080252			ORNAN28849
Xenopus tropicalis	100216154		Xenbase:XB-GENE-494652

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements