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primase and DNA directed polymerase

Summary

Gene Symbol

PRIMPOL

Organism

Homo sapiens (human)

External Links

NCBI Gene

201973

PubChem

201973

Alliance of Genome Resources

HGNC:26575

Annotation

Keyword

3D-structure
Alternative splicing
Chromosome
Coiled coil
DNA repair
DNA-directed DNA polymerase
DNA-directed RNA polymerase
Disease variant
Manganese
Metal-binding
Mitochondrion
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A5S6SZ32
Q96LW4	Coiled-coil domain-containing protein 111

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

1

2

3

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GO Term	Evidence Code	PMID
mitochondrial DNA replication	IMP	24207056
mitochondrial DNA replication	IBA
DNA replication, synthesis of RNA primer	IEA
response to UV	IDA	24240614 24267451
response to UV	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication [inference]

mitochondrial DNA replication

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA repair

mitochondrial DNA metabolic process [inference]

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication [inference]

mitochondrial DNA replication

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA repair

mitochondrial DNA metabolic process [inference]

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication [inference]

mitochondrial DNA replication

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA repair

mitochondrial DNA metabolic process [inference]

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication [inference]

mitochondrial DNA replication

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA repair

mitochondrial DNA metabolic process [inference]

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication [inference]

mitochondrial DNA replication

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA repair

mitochondrial DNA metabolic process [inference]

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication [inference]

mitochondrial DNA replication

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA repair

mitochondrial DNA metabolic process [inference]

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication [inference]

mitochondrial DNA replication

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA repair

mitochondrial DNA metabolic process [inference]

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication [inference]

mitochondrial DNA replication

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA repair

mitochondrial DNA metabolic process [inference]

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication [inference]

mitochondrial DNA replication

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA repair

mitochondrial DNA metabolic process [inference]

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication [inference]

mitochondrial DNA replication

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA repair

mitochondrial DNA metabolic process [inference]

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis

error-prone translesion synthesis

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

R-loop processing

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA repair

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

postreplication repair [inference]

translesion synthesis

error-prone translesion synthesis

mitochondrial DNA repair

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
DNA-directed RNA polymerase complex	IEA
nucleus	IDA	24207056 24240614
nucleus	IBA
replication fork	IDA	28534480
mitochondrion	HTP	34800366

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex

cellular anatomical entity [inference]

replication fork

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
chromatin binding	IDA	24240614 28534480
chromatin binding	IBA
DNA-directed DNA polymerase activity	IDA	24126761 24207056 25746449
DNA-directed DNA polymerase activity	IBA
DNA primase activity

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

RNA polymerase activity [inference]

5'-3' RNA polymerase activity [inference]

DNA-directed 5'-3' RNA polymerase activity

DNA primase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

catalytic activity, acting on RNA [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity [inference]

DNA-directed 5'-3' RNA polymerase activity

DNA primase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

protein-containing complex binding [inference]

chromatin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dna-directed primase/polymerase protein

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 6** entries
Gene Ontology
DNA replication, synthesis of RNA primer
chromatin binding
error-prone translesion synthesis
mitochondrial DNA replication
response to UV
translesion synthesis

Displaying 1 entry
InterPro
DNA-directed primase/polymerase protein

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:11830	myopia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements