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C-C motif chemokine ligand 11

Summary

Gene Symbol

Ccl11

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20292

PubChem

20292

Alliance of Genome Resources

MGI:103576

Annotation

Keyword

Chemotaxis
Cytokine
Disulfide bond
Glycoprotein
Inflammatory response
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P48298	C-C motif chemokine 11 Eosinophil chemotactic protein Small-inducible cytokine A11

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 23** of 23 in total

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GO Term	Evidence Code	PMID
inflammatory response	IBA
learning or memory	IDA	21886162
positive regulation of GTPase activity	IEA ISO

GO Hierarchy

biological process

immune system process [inference]

immune response

humoral immune response [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

leukocyte migration [inference]

leukocyte chemotaxis [inference]

mast cell chemotaxis

granulocyte chemotaxis [inference]

eosinophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

eosinophil chemotaxis

eosinophil migration [inference]

eosinophil chemotaxis

mast cell migration [inference]

mast cell chemotaxis

cellular process [inference]

cell killing [inference]

killing of cells of another organism

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

intracellular signal transduction [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

mast cell chemotaxis

granulocyte chemotaxis [inference]

eosinophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

eosinophil chemotaxis

eosinophil migration [inference]

eosinophil chemotaxis

mast cell migration [inference]

mast cell chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

mast cell chemotaxis

granulocyte chemotaxis [inference]

eosinophil chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

supramolecular fiber organization [inference]

actin filament organization

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in mammary gland duct morphogenesis

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in mammary gland duct morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in mammary gland duct morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in mammary gland duct morphogenesis

growth [inference]

developmental growth [inference]

developmental growth involved in morphogenesis [inference]

mammary duct terminal end bud growth

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

mast cell chemotaxis

granulocyte chemotaxis [inference]

eosinophil chemotaxis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

chronic inflammatory response

defense response to other organism [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

immune response

humoral immune response [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

antimicrobial humoral immune response mediated by antimicrobial peptide

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis

negative regulation of nervous system development [inference]

negative regulation of neurogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of angiogenesis [inference]

positive regulation of angiogenesis

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis

regulation of neurogenesis [inference]

negative regulation of neurogenesis

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis

negative regulation of nervous system development [inference]

negative regulation of neurogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis

negative regulation of nervous system development [inference]

negative regulation of neurogenesis

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

intracellular signal transduction [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis

regulation of neurogenesis [inference]

negative regulation of neurogenesis

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis

negative regulation of nervous system development [inference]

negative regulation of neurogenesis

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of biological quality [inference]

regulation of cell shape

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular space	IBA IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
receptor ligand activity	ISO
protein dimerization activity	IEA ISO
chemokine activity	IBA IEA ISO
CCR3 chemokine receptor binding	IEA ISO
CCR chemokine receptor binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

chemokine receptor binding [inference]

chemokine activity

CCR chemokine receptor binding

CCR3 chemokine receptor binding

cytokine receptor binding [inference]

chemokine receptor binding [inference]

chemokine activity

CCR chemokine receptor binding

CCR3 chemokine receptor binding

receptor ligand activity

cytokine activity [inference]

chemokine activity

protein dimerization activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity [inference]

chemokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity [inference]

chemokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Chemokine interleukin-8-like domain

Functional Category

I: Lipid transport and metabolism
J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
cell chemotaxis
chemokine activity
chemotaxis
cytokine activity
eosinophil chemotaxis
immune response

Displaying **all 4** entries
InterPro
CC chemokine, conserved site
Chemokine beta/gamma/delta
Chemokine interleukin-8-like domain
Chemokine interleukin-8-like superfamily

Disease

Disease Ontology

Displaying entries **21 - 22** of 22 in total

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DO ID	Disease Name	Source
DOID:9675	pulmonary emphysema	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 52** of 52 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Chionomys nivalis	130878226	269649_0:001ea7
Peromyscus eremicus	131916264	42410_0:002c65

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Last updated: December 9, 2024