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sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

Summary

Gene Symbol

Sema3c

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20348

PubChem

20348

Alliance of Genome Resources

MGI:107557

Annotation

Keyword

Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Neurogenesis
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q62181	Semaphorin-E

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	IDA	26053665
cardiac right ventricle morphogenesis	IEP	19666519
outflow tract morphogenesis	IEP	19666519
pulmonary myocardium development	IEP	19666519
blood vessel remodeling	IMP	11688556

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

cardiac endothelial to mesenchymal transition

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

somitogenesis

segmentation [inference]

somitogenesis

post-embryonic development

tissue remodeling [inference]

blood vessel remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

outflow tract morphogenesis

cardiac chamber morphogenesis [inference]

cardiac ventricle morphogenesis [inference]

cardiac right ventricle morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

dichotomous subdivision of an epithelial terminal unit [inference]

dichotomous subdivision of terminal units involved in salivary gland branching

cardiac septum morphogenesis [inference]

outflow tract septum morphogenesis

anatomical structure formation involved in morphogenesis [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

neural tube development

muscle tissue development [inference]

striated muscle tissue development [inference]

pulmonary myocardium development

tube development [inference]

neural tube development

animal organ development [inference]

heart development

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

cardiac endothelial to mesenchymal transition

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [inference]

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [inference]

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
collagen-containing extracellular matrix	HDA	22159717
plasma membrane	IBA
extracellular space	HDA IBA IDA	15239958 24006456

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

Displaying **all 3** entries
GO Term	Evidence Code	PMID
neuropilin binding	IBA
chemorepellent activity	IBA
semaphorin receptor binding	IBA IPI	15239958

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

chemorepellent activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Semaphorin

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis

Displaying **all 6** entries
Gene Ontology
chemorepellent activity
negative regulation of axon extension involved in axon guidance
neural crest cell migration
positive regulation of cell migration
semaphorin receptor binding
semaphorin-plexin signaling pathway

Displaying **all 9** entries
InterPro
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
PSI domain
Sema domain superfamily
Sema domain
Semaphorin
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:7148	rheumatoid arthritis	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of **129** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Nomascus leucogenys	100602982		NOMLE03686
Sus scrofa	100624508		PIGXX36320
Loxodonta africana	100665779		LOXAF17749
Oreochromis niloticus	100697969		ORENI24793
Cavia porcellus	100730457	10141_0:0025b4	CAVPO14296
Cricetulus griseus	100765927	10029_0:000255	CRIGR13282
Sarcophilus harrisii	100915955		SARHA03040
Otolemur garnettii	100962931		OTOGA17862
Pan paniscus	100984137		PANPA36543
Papio anubis	101019247		PAPAN30491