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ceramide synthase 3

Summary

Gene Symbol

CERS3

Aliases

MGC27091

Organism

Homo sapiens (human)

External Links

NCBI Gene

204219

HGNC

23752

KEGG Gene ID

hsa:204219

PubChem

204219

Alliance of Genome Resources

HGNC:23752

Annotation

Keyword

Endoplasmic reticulum
Ichthyosis
Lipid biosynthesis
Phosphoprotein
Reference proteome
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IU89	Dihydroceramide synthase 3 LAG1 longevity assurance homolog 3 Sphingosine N-acyltransferase CERS3 Ultra-long-chain ceramide synthase CERS3 Very-long-chain ceramide synthase CERS3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ceramide biosynthetic process	IBA IDA IMP	17977534 22038835 23754960
keratinocyte differentiation	IMP	23754960
epidermis development	ISS
cornification	ISS
sphingolipid biosynthetic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

amide metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

amide biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

cornification

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	ISS
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
DNA binding	IEA
sphingosine N-acyltransferase activity	IBA IDA TAS	17977534 22038835
protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

N-acyltransferase activity [inference]

sphingosine N-acyltransferase activity

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000154227

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K24622

Name

very-long-chain ceramide synthase / ultra-long-chain ceramide synthase [EC:2.3.1.297 2.3.1.298]

References

16753040

Rhea

RHEA:61492

an ultra-long-chain fatty acyl-CoA + a sphingoid base

an N-(ultra-long-chain-acyl)-sphingoid base + H⁺ + CoA

Enzyme

2.3.1.298

PMID

RHEA:23768

sphing-4-enine + a fatty acyl-CoA

H⁺ + an N-acylsphing-4-enine + CoA

Enzyme

2.3.1.24

PMID

RHEA:61480

a very long-chain fatty acyl-CoA + a sphingoid base

an N-(very-long-chain fatty acyl)-sphingoid base + H⁺ + CoA

Enzyme

2.3.1.297

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 32 in total

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DO ID	Disease Name	Source
DOID:0050428	nonepidermolytic palmoplantar keratoderma	DisGeNET
DOID:0050475	Weill-Marchesani syndrome	DisGeNET
DOID:0060655	autosomal recessive congenital ichthyosis	DisGeNET DisGeNET
DOID:0060656	autosomal recessive congenital ichthyosis 1	DisGeNET DisGeNET
DOID:0060710	autosomal recessive congenital ichthyosis 2	DisGeNET
DOID:0060711	autosomal recessive congenital ichthyosis 3	DisGeNET
DOID:0060712	autosomal recessive congenital ichthyosis 4A	DisGeNET
DOID:0060714	autosomal recessive congenital ichthyosis 5	DisGeNET
DOID:0060715	autosomal recessive congenital ichthyosis 6	DisGeNET
DOID:0060716	autosomal recessive congenital ichthyosis 7	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 18 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000365	Hearing impairment
HP:0000491	Keratitis
HP:0000656	Ectropion
HP:0000962	Hyperkeratosis
HP:0000966	Hypohidrosis
HP:0000982	Palmoplantar keratoderma
HP:0000989	Pruritus
HP:0001019	Erythroderma
HP:0001508	Failure to thrive

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:615023	autosomal recessive congenital ichthyosis 9
ORPHA:79394	congenital non-bullous ichthyosiform erythroderma

PubChem Disease

MedGen Diseases

Autosomal recessive congenital ichthyosis 9

OMIM Phenotypes

ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 9; ARCI9

KEGG Diseases

Autosomal recessive congenital ichthyosis

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012383
Gene Name: ceramide synthase 3

Ortholog

Displaying entries **1 - 10** of 61 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	180743	WB:WBGene00002044
Drosophila melanogaster	50392	FB:FBgn0040918
Danio rerio	100141367	ZFIN:ZDB-GENE-080220-32
Danio rerio	100332380	ZFIN:ZDB-GENE-130320-1
Xenopus laevis	379135	Xenbase:XB-GENE-6251639
Xenopus laevis	444162	Xenbase:XB-GENE-957273
Xenopus tropicalis	448139	Xenbase:XB-GENE-957267
Chrysemys picta bellii	101947682		CHRPI05794
Serinus canaria	103816094		SERCA10473
Ornithorhynchus anatinus	100090484		ORNAN22879

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UniCarb-DR

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Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements