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epoxide hydrolase 2

Summary

Gene Symbol

EPHX2

Aliases

ABHD20
bifunctional epoxide hydrolase
sEH
soluble epoxide hydrolase

Organism

Homo sapiens (human)

External Links

NCBI Gene

2053

HGNC

3402

KEGG Gene ID

hsa:2053

PubChem

2053

Alliance of Genome Resources

HGNC:3402

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Aromatic hydrocarbons catabolism
Cytoplasm
Detoxification
Direct protein sequencing
Hydrolase
Lipid metabolism
Lipoprotein
Magnesium
Metal-binding
Multifunctional enzyme
Peroxisome
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P34913

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
response to toxic substance	IEA
dephosphorylation	IDA	12574508 22217705
positive regulation of gene expression	IDA	18974052
stilbene catabolic process	IDA	8342951
epoxide metabolic process	IDA	21217101 22798687

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

stilbene catabolic process

organic substance catabolic process [inference]

olefinic compound catabolic process [inference]

stilbene catabolic process

organic cyclic compound catabolic process [inference]

stilbene catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound catabolic process [inference]

stilbene catabolic process

benzene-containing compound metabolic process [inference]

stilbene metabolic process [inference]

stilbene catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation

phospholipid dephosphorylation

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

stilbene catabolic process

cellular lipid metabolic process [inference]

lipid modification [inference]

phospholipid dephosphorylation

heterocycle metabolic process [inference]

epoxide metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

phospholipid dephosphorylation

small molecule metabolic process [inference]

ether metabolic process [inference]

epoxide metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

phospholipid dephosphorylation

ether metabolic process [inference]

epoxide metabolic process

olefinic compound metabolic process [inference]

stilbene metabolic process [inference]

stilbene catabolic process

olefinic compound catabolic process [inference]

stilbene catabolic process

organic cyclic compound metabolic process [inference]

benzene-containing compound metabolic process [inference]

stilbene metabolic process [inference]

stilbene catabolic process

epoxide metabolic process

organic cyclic compound catabolic process [inference]

stilbene catabolic process

organic substance catabolic process [inference]

olefinic compound catabolic process [inference]

stilbene catabolic process

organic cyclic compound catabolic process [inference]

stilbene catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound catabolic process [inference]

stilbene catabolic process

benzene-containing compound metabolic process [inference]

stilbene metabolic process [inference]

stilbene catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation

phospholipid dephosphorylation

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

stilbene catabolic process

cellular lipid metabolic process [inference]

lipid modification [inference]

phospholipid dephosphorylation

heterocycle metabolic process [inference]

epoxide metabolic process

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of small molecule metabolic process [inference]

regulation of cholesterol metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

regulation of cholesterol metabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

Displaying **all 4** entries
GO Term	Evidence Code	PMID
peroxisome	IBA IDA	16314446 18513744
peroxisomal matrix	TAS
cytosol	IDA TAS	16314446 18513744 8342951
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 8 in total

1

2

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Last »
GO Term	Evidence Code	PMID
lipid phosphatase activity	IBA IDA	12574510
epoxide hydrolase activity	IDA	10862610 21217101 22798687 8342951
phosphatase activity	IDA	12574508 15196990
toxic substance binding	IDA	15096040
magnesium ion binding	IBA IDA	12574510