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solute carrier family 3, member 1

Summary

Gene Symbol

Slc3a1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20532

PubChem

20532

Alliance of Genome Resources

MGI:1195264

Annotation

Keyword

Amino-acid transport
Calcium
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Metal-binding
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q91WV7	D2 Neutral and basic amino acid transport protein Solute carrier family 3 member 1 b(0,+)-type amino acid transporter-related heavy chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
L-glutamate transmembrane transport	IDA	26739563
L-cystine transport	IDA	26739563
aspartate transmembrane transport	IDA	26739563
amino acid transport	IBA ISO
carbohydrate metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

transmembrane transport [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

modified amino acid transport [inference]

L-cystine transport

nitrogen compound transport [inference]

amino acid transport

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

amide transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

modified amino acid transport [inference]

L-cystine transport

sulfur compound transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

Displaying **all 4** entries
GO Term	Evidence Code	PMID
apical plasma membrane	IPI	26739563
mitochondrial inner membrane	HDA	12865426
vacuolar membrane	IEA ISO
brush border membrane	IDA ISO	12167606

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

bounding membrane of organelle [inference]

vacuolar membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12167606 15757906 26739563
protein-containing complex binding	IEA ISO
protein heterodimerization activity	IPI ISO	26739563
metal ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

protein dimerization activity [inference]

protein heterodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Glycosyl hydrolase, family 13, catalytic domain

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
glucan 1,4-alpha-maltotriohydrolase activity
maltose alpha-glucosidase activity
maltose catabolic process
oligo-1,6-glucosidase activity
sucrose alpha-glucosidase activity
sucrose catabolic process

Displaying **all 4** entries
InterPro
Glycoside hydrolase superfamily
Glycosyl hydrolase, all-beta
Glycosyl hydrolase, family 13, catalytic domain
Oligo-1,6-glucosidase, domain 2

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9266	cystinuria	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **140** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6519		HGNC:11025	HUMAN62462
Rattus norvegicus	29484	10116_1:0024e3	RGD:3709	RATNO35173
Drosophila melanogaster	34597		FB:FBgn0032381
Drosophila melanogaster	34598		FB:FBgn0032382
Drosophila melanogaster	35824		FB:FBgn0002570
Drosophila melanogaster	35825		FB:FBgn0002569
Drosophila melanogaster	35826		FB:FBgn0002571
Drosophila melanogaster	35827		FB:FBgn0033294
Drosophila melanogaster	35828		FB:FBgn0050359
Drosophila melanogaster	35829		FB:FBgn0033296

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements