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solute carrier family 5 (sodium/glucose cotransporter), member 1

Summary

Gene Symbol

Slc5a1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20537

PubChem

20537

Alliance of Genome Resources

MGI:107678

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Proteomics identification
Reference proteome
Sodium transport
Sugar transport
Symport
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q8C3K6	High affinity sodium-glucose cotransporter Solute carrier family 5 member 1
Q9QXI6	High affinity sodium-glucose cotransporter Solute carrier family 5 member 1
Q8CCA7	High affinity sodium-glucose cotransporter Solute carrier family 5 member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
alpha-glucoside transport	ISO
metanephros development	IMP	10997927
intestinal D-glucose absorption	IMP	22124465
sodium ion transport	IBA
water transport	IEA

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

galactose transmembrane transport

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

renal system process [inference]

renal absorption [inference]

renal glucose absorption

digestive system process [inference]

intestinal absorption

intestinal hexose absorption [inference]

intestinal D-glucose absorption

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

kidney development [inference]

metanephros development

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

vascular transport [inference]

transport across blood-brain barrier

fluid transport [inference]

water transport

transepithelial water transport

epithelial fluid transport [inference]

transepithelial water transport

intestinal absorption

intestinal hexose absorption [inference]

intestinal D-glucose absorption

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

galactose transmembrane transport

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

transepithelial transport [inference]

epithelial fluid transport [inference]

transepithelial water transport

organic substance transport [inference]

water transport

transepithelial water transport

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

galactose transmembrane transport

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

intestinal hexose absorption [inference]

intestinal D-glucose absorption

carbohydrate derivative transport [inference]

glycoside transport [inference]

glucoside transport [inference]

alpha-glucoside transport

import into cell [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

biological regulation [inference]

regulation of molecular function [inference]

regulation of transporter activity

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
early endosome	ISO
plasma membrane	ISO
plasma membrane	IBA
brush border	IDA	15601832
cell-cell junction	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

perinuclear region of cytoplasm

cluster of actin-based cell projections [inference]

brush border

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
glucose transmembrane transporter activity
water transmembrane transporter activity	ISS
water transmembrane transporter activity	ISO
glucose:sodium symporter activity	ISS
glucose:sodium symporter activity	ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

carbohydrate transmembrane transporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

galactose transmembrane transporter activity [inference]

galactose:sodium symporter activity

glucose transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

water transmembrane transporter activity

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

carbohydrate:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

carbohydrate derivative transmembrane transporter activity [inference]

glucoside transmembrane transporter activity [inference]

alpha-glucoside transmembrane transporter activity

salt transmembrane transporter activity [inference]

water transmembrane transporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Sodium/glucose symporter superfamily
Sodium/solute symporter

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6523	Xenbase:XB-GENE-855699	HUMAN60154
Xenopus tropicalis	6527	Xenbase:XB-GENE-855699
Saccharomyces cerevisiae S288C	6528	SGD:S000001008
Xenopus tropicalis	20537	Xenbase:XB-GENE-855699
Rattus norvegicus	25552	Xenbase:XB-GENE-855699	RATNO08732
Xenopus tropicalis	64452	Xenbase:XB-GENE-855699
Saccharomyces cerevisiae S288C	64522	SGD:S000001008
Saccharomyces cerevisiae S288C	109342	SGD:S000001008
Saccharomyces cerevisiae S288C	114613	SGD:S000001008
Saccharomyces cerevisiae S288C	216225	SGD:S000001008