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ERCC excision repair 5, endonuclease

Summary

Gene Symbol

ERCC5

Organism

Homo sapiens (human)

External Links

NCBI Gene

2073

PubChem

2073

Alliance of Genome Resources

HGNC:3437

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Chromosome
Cockayne syndrome
DNA repair
DNA-binding
Deafness
Disease variant
Dwarfism
Endonuclease
Magnesium
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Xeroderma pigmentosum

Proteins

Displaying 1 entry
UniProt	Protein Name
P28715	DNA repair protein complementing XP-G cells Xeroderma pigmentosum group G-complementing protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
transcription-coupled nucleotide-excision repair	IMP TAS	16246722
negative regulation of apoptotic process	IMP	16167068
response to UV	IDA IMP	16167068 8710877
response to UV-C	IMP	17208056
base-excision repair, AP site formation	IDA	9927729

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV

response to UV-C

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

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GO Term	Evidence Code	PMID
protein-containing complex	IDA	26833090
nucleoplasm	TAS
nucleotide-excision repair complex	IDA	11259578
nucleus	IBA IDA	26833090 8710877
chromosome

GO Hierarchy

cellular component

protein-containing complex

nuclear protein-containing complex [inference]

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	15358233 16246722 17268471 26833090 8652557 9305916 9927729
protein-containing complex binding	IDA	11259578
enzyme activator activity	IDA	9927729
RNA polymerase II complex binding	IDA	16246722
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity

endodeoxyribonuclease activity

DNA nuclease activity [inference]

endodeoxyribonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

endodeoxyribonuclease activity

binding [inference]

protein binding

basal transcription machinery binding [inference]

basal RNA polymerase II transcription machinery binding [inference]

RNA polymerase II complex binding

enzyme binding [inference]

RNA polymerase binding [inference]

RNA polymerase core enzyme binding [inference]

RNA polymerase II complex binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

DNA secondary structure binding [inference]

bubble DNA binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity

molecular function activator activity [inference]

enzyme activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA repair protein

Functional Category

I: Lipid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
DNA endonuclease activity
DNA repair
catalytic activity
endonuclease activity
hydrolase activity, acting on ester bonds
hydrolase activity
metal ion binding
nuclease activity

Displaying **all 8** entries
InterPro
5'-3' exonuclease, C-terminal domain superfamily
Helix-hairpin-helix motif, class 2
PIN-like domain superfamily
XPG conserved site
XPG, N-terminal
XPG-I domain
XPG/Rad2 endonuclease, eukaryotes
XPG/Rad2 endonuclease

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:0050117	disease by infectious agent	Alliance of Genome Resources
DOID:0080913	cerebrooculofacioskeletal syndrome 3	Alliance of Genome Resources
DOID:0110849	xeroderma pigmentosum group G	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:1909	melanoma	Alliance of Genome Resources
DOID:2596	larynx cancer	Alliance of Genome Resources
DOID:2962	Cockayne syndrome	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	22592	MGI:103582	MOUSE27326
Caenorhabditis elegans	186441	WB:WBGene00019004
Rattus norvegicus	301382	RGD:1586176	RATNO42308
Xenopus laevis	397963	Xenbase:XB-GENE-960384
Bos taurus	509602		BOVIN04100
Danio rerio	541502	ZFIN:ZDB-GENE-050327-28	DANRE17302
Macaca mulatta	707822		MACMU16425
Saccharomyces cerevisiae S288C	853174	SGD:S000003490
Drosophila melanogaster	3772069	FB:FBgn0002887
Ornithorhynchus anatinus	100082792		ORNAN01609

GlyTouCan

GlyComb

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UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements