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ERCC excision repair 5, endonuclease

Summary

Gene Symbol

ERCC5

Organism

Homo sapiens (human)

External Links

NCBI Gene

2073

PubChem

2073

Alliance of Genome Resources

HGNC:3437

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Chromosome
Cockayne syndrome
DNA repair
DNA-binding
Deafness
Disease variant
Dwarfism
Endonuclease
Magnesium
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Xeroderma pigmentosum

Proteins

Displaying 1 entry
UniProt	Protein Name
P28715	DNA repair protein complementing XP-G cells Xeroderma pigmentosum group G-complementing protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
double-strand break repair via homologous recombination	IMP	26833090
transcription-coupled nucleotide-excision repair	TAS
transcription-coupled nucleotide-excision repair	IMP	16246722
base-excision repair, AP site formation	IDA	9927729
nucleotide-excision repair	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

base-excision repair, AP site formation

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV

response to UV-C

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

nucleotide-excision repair

transcription-coupled nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via homologous recombination

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleotide-excision repair complex	IDA	11259578
nucleus	IDA	26833090 8710877
nucleus	IBA
nucleoplasm	TAS
DNA replication factor A complex	IDA	7700386

GO Hierarchy

cellular component

protein-containing complex

nuclear protein-containing complex [inference]

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
bubble DNA binding	IDA	16246722 32821917
RNA polymerase II complex binding	IDA	16246722
damaged DNA binding	IDA	32821917
double-stranded DNA binding	IDA	12644470 8090225
single-stranded DNA binding	IDA	12644470

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity

endodeoxyribonuclease activity

DNA nuclease activity [inference]

endodeoxyribonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

endodeoxyribonuclease activity

binding [inference]

protein binding

basal transcription machinery binding [inference]

basal RNA polymerase II transcription machinery binding [inference]

RNA polymerase II complex binding

enzyme binding [inference]

RNA polymerase binding [inference]

RNA polymerase core enzyme binding [inference]

RNA polymerase II complex binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

DNA secondary structure binding [inference]

bubble DNA binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity

molecular function activator activity [inference]

enzyme activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA repair protein

Functional Category

I: Lipid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
DNA endonuclease activity
DNA repair
catalytic activity
endonuclease activity
hydrolase activity, acting on ester bonds
hydrolase activity
metal ion binding
nuclease activity

Displaying **all 8** entries
InterPro
5'-3' exonuclease, C-terminal domain superfamily
Helix-hairpin-helix motif, class 2
PIN-like domain superfamily
XPG conserved site
XPG, N-terminal
XPG-I domain
XPG/Rad2 endonuclease, eukaryotes
XPG/Rad2 endonuclease

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050117	disease by infectious agent	Alliance of Genome Resources
DOID:0080913	cerebrooculofacioskeletal syndrome 3	Alliance of Genome Resources
DOID:0110849	xeroderma pigmentosum group G	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:1909	melanoma	Alliance of Genome Resources
DOID:2596	larynx cancer	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 46 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	2073	Xenbase:XB-GENE-960380
Mus musculus	22592		MOUSE27326
Rattus norvegicus	301382		RATNO42308
Bos taurus	509602		BOVIN04100
Danio rerio	541502		DANRE17302
Macaca mulatta	707822		MACMU16425
Ornithorhynchus anatinus	100082792		ORNAN01609
Taeniopygia guttata	100226677		TAEGU10726
Callithrix jacchus	100393826		CALJA20496
Macaca mulatta	100426213		MACMU16425