GlyCosmos Portal

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GO Term	Evidence Code	PMID
signaling receptor binding	IBA ISO
protein-containing complex binding	ISO
enzyme binding	ISO
ephrin receptor binding	IPI ISO	12925710
protein tyrosine kinase activity	EXP IDA IMP ISO TAS	12091389 14636584 22759635 27505886 8910389

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

protein kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

binding [inference]

protein binding

signaling receptor binding

receptor serine/threonine kinase binding [inference]

transmembrane receptor protein serine/threonine kinase binding [inference]

BMP receptor binding

ephrin receptor binding

transcription factor binding [inference]

DNA-binding transcription factor binding [inference]

RNA polymerase II-specific DNA-binding transcription factor binding [inference]

nuclear receptor binding [inference]

nuclear estrogen receptor binding

enzyme binding

kinase binding [inference]

protein kinase binding

protein kinase C binding

phospholipase binding

protein domain specific binding

SH2 domain binding

transmembrane transporter binding

cell adhesion molecule binding

integrin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding

integrin binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

lipase activator activity [inference]

phospholipase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

lipase activator activity [inference]

phospholipase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

proto-oncogene tyrosine-protein kinase Src

Functional Category

K: Transcription
T: Signal transduction mechanisms

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Gene Ontology
ATP binding
bone resorption
epidermal growth factor receptor signaling pathway
kinase activity
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway
non-membrane spanning protein tyrosine kinase activity
nucleotide binding
osteoclast development
phosphorylation

Displaying **all 10** entries
InterPro
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
SH2 domain superfamily
SH2 domain
SH3 domain
SH3-like domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain
Tyrosine-protein kinase, active site
Tyrosine-protein kinase, catalytic domain

Disease

Disease Ontology

Displaying entries **1 - 10** of 25 in total

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DO ID	Disease Name	Source
DOID:0060074	ductal carcinoma in situ	Alliance of Genome Resources
DOID:0080199	colorectal carcinoma	Alliance of Genome Resources
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:10155	intestinal cancer	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1520	colon carcinoma	Alliance of Genome Resources
DOID:1588	thrombocytopenia	Alliance of Genome Resources
DOID:162	cancer	Alliance of Genome Resources

Ortholog

Displaying entries **81 - 90** of **121** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Athene cunicularia	113487500		ATHCN16731
Electrophorus electricus	113576303		ELEEL18521
Bos indicus x Bos taurus	113903050		BOBOX02204
Vombatus ursinus	114046691		VOMUR20068
Marmota flaviventris	114100432	93162_0:0020f4
Podarcis muralis	114599561		PODMU06433
Grammomys surdaster	114638182	491861_0:003815
Peromyscus leucopus	114681835	10041_0:001930
Echeneis naucrates	115045715		ECHNA00970
Salmo trutta	115165589		SALTR87510

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OrthoDB (Group)

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Acknowledgements