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AKT serine/threonine kinase 2
Summary
- Gene Symbol
-
- AKT2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Apoptosis
- Cell membrane
- Cytoplasm
- Developmental protein
- Diabetes mellitus
- Disease variant
- Disulfide bond
- Endosome
- Glucose metabolism
- Glycogen biosynthesis
- Glycogen metabolism
- Glycoprotein
- Manganese
- Metal-binding
- Nucleus
- Phosphoprotein
- Proto-oncogene
- Reference proteome
- Serine/threonine-protein kinase
- Sugar transport
- Translation regulation
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of fatty acid beta-oxidation | ||
| protein stabilization | ||
| positive regulation of cell motility | ||
| positive regulation of protein targeting to membrane | ||
| regulation of cell migration |
GO Hierarchy
- regulation of cell cycle
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of transmembrane transport [inference]
positive regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| early endosome | ||
| cell cortex | ||
| ruffle membrane | ||
| intracellular membrane-bounded organelle | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| protein serine kinase activity | ||
| metal ion binding | ||
| protein serine/threonine kinase activity | ||
| molecular function activator activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- kinase
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
| transferase activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0112263 | hypoinsulinemic hypoglycemia with hemihypertrophy | |
| DOID:10283 | prostate cancer | |
| DOID:10286 | prostate carcinoma | |
| DOID:10763 | hypertension | |
| DOID:11612 | polycystic ovary syndrome | |
| DOID:1380 | endometrial cancer | |
| DOID:14330 | Parkinson's disease | |
| DOID:1574 | alcohol use disorder | |
| DOID:162 | cancer | |
| DOID:2526 | prostate adenocarcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 11652 | MGI:104874 | MOUSE52616 | ||
| 25233 | RGD:2082 | RATNO15597 | ||
| 41957 | FB:FBgn0010379 | |||
| 179424 | WB:WBGene00000102 | |||
| 378972 | ZFIN:ZDB-GENE-031007-5 | DANRE14281 | ||
| 379783 | Xenbase:XB-GENE-484172 | |||
| 403146 | ZFIN:ZDB-GENE-040121-5 | |||
| 432172 | Xenbase:XB-GENE-17345542 | |||
| 449021 | CANLF01064 | |||
| 456035 | PANTR18306 |
