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interleukin 23 receptor

Summary

Gene Symbol

Il23r

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

209590

PubChem

209590

Alliance of Genome Resources

MGI:2181693

Annotation

Keyword

Cell membrane
Glycoprotein
Inflammatory response
Innate immunity
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
G5E8U4
Q8K4B4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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2

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IBA
negative regulation of interleukin-10 production	IEA ISO
positive regulation of T-helper 1 type immune response	IEA ISO
positive regulation of defense response to virus by host	IEA ISO
positive regulation of type II interferon production	IEA ISO

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

interleukin-23-mediated signaling pathway

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide

response to cytokine [inference]

response to type II interferon

response to oxygen-containing compound [inference]

response to lipopolysaccharide

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 type immune response

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

negative regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

negative regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

negative regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of defense response to virus [inference]

regulation of defense response to virus by host [inference]

positive regulation of defense response to virus by host

regulation of response to external stimulus [inference]

regulation of defense response to virus [inference]

regulation of defense response to virus by host [inference]

positive regulation of defense response to virus by host

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 type immune response

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of defense response to virus [inference]

regulation of defense response to virus by host [inference]

positive regulation of defense response to virus by host

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

interleukin-23-mediated signaling pathway

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

negative regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of cytokine production [inference]

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-10 production [inference]

negative regulation of interleukin-10 production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

Displaying **all 5** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
receptor complex	ISO	23382219
plasma membrane	ISO TAS	12023369
cell surface	IEA
interleukin-23 receptor complex	IBA IEA ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

plasma membrane signaling receptor complex [inference]

interleukin-23 receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

interleukin-23 receptor complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytokine receptor activity	IBA
interleukin-12 receptor binding	IBA IEA ISO
interleukin-23 receptor activity	ISO	12023369
interleukin-23 binding	IBA ISO	12023369
cytokine binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

interleukin-12 receptor binding

growth factor receptor binding [inference]

interleukin-12 receptor binding

cytokine binding

interleukin-23 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

interleukin-23 receptor activity

immune receptor activity [inference]

cytokine receptor activity

interleukin-23 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

interleukin-23 receptor

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism

Displaying 1 entry
Gene Ontology
interleukin-27 receptor activity

Disease

Disease Ontology

Displaying entries **1 - 10** of 21 in total

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DO ID	Disease Name	Source
DOID:0081120	Graves ophthalmopathy	Alliance of Genome Resources
DOID:0110883	inflammatory bowel disease 17	Alliance of Genome Resources
DOID:0111279	psoriasis 7	Alliance of Genome Resources
DOID:10159	osteonecrosis	Alliance of Genome Resources
DOID:10608	celiac disease	Alliance of Genome Resources
DOID:11335	sarcoidosis	Alliance of Genome Resources
DOID:12361	Graves' disease	Alliance of Genome Resources
DOID:12894	Sjogren's syndrome	Alliance of Genome Resources
DOID:13141	uveitis	Alliance of Genome Resources
DOID:13241	Behcet's disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	149233		HGNC:19100	HUMAN50322
Canis lupus familiaris	609732			CANLF15616
Bos taurus	614367			BOVIN26759
Rattus norvegicus	689932	10116_1:001a87	RGD:1586368	RATNO29934
Macaca mulatta	700440			MACMU22985
Sus scrofa	733613			PIGXX30171
Pan troglodytes	744045			PANTR21334
Equus caballus	100053807			HORSE35118
Ornithorhynchus anatinus	100081726			ORNAN09527
Danio rerio	100134972		ZFIN:ZDB-GENE-080107-5

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements