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ATP binding cassette subfamily A member 3

Summary

Gene Symbol

ABCA3

Organism

Homo sapiens (human)

External Links

NCBI Gene

PubChem

Alliance of Genome Resources

HGNC:33

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cytoplasmic vesicle
Disease variant
Disulfide bond
Endosome
Glycoprotein
Lipid transport
Lysosome
Reference proteome
Repeat
Translocase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q99758	ABC-C transporter ATP-binding cassette sub-family A member 3 ATP-binding cassette transporter 3 Xenobiotic-transporting ATPase ABCA3
Q4LE27

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
phospholipid transport	IMP	28887056
xenobiotic transmembrane transport	IMP	26903515
regulation of lipid biosynthetic process	IEA
positive regulation of cholesterol efflux	IMP	25817392
regulation of phosphatidylcholine metabolic process	IMP	25817392 31473345

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

transmembrane transport [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly

cellular component assembly [inference]

organelle assembly

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation

intermembrane lipid transfer

export from cell [inference]

xenobiotic export from cell

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

lung development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

chemical homeostasis [inference]

lipid homeostasis [inference]

phospholipid homeostasis

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

localization [inference]

establishment of localization [inference]

transport [inference]

xenobiotic transport

transmembrane transport [inference]

organic substance transport [inference]

lipid transport

organophosphate ester transport [inference]

phospholipid transport

export from cell [inference]

xenobiotic export from cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of lipid biosynthetic process

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phosphatidylcholine metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of phosphatidylcholine metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of lipid biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phosphatidylcholine metabolic process

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of phospholipid transport [inference]

regulation of phospholipid efflux [inference]

positive regulation of phospholipid efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of phospholipid transport [inference]

regulation of phospholipid efflux [inference]

positive regulation of phospholipid efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of phospholipid transport

positive regulation of phospholipid efflux

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phosphatidylcholine metabolic process

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

regulation of protein oligomerization [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

regulation of protein homooligomerization [inference]

positive regulation of protein homooligomerization

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

regulation of protein oligomerization [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

regulation of protein homooligomerization [inference]

positive regulation of protein homooligomerization

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein oligomerization [inference]

positive regulation of protein homooligomerization

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
alveolar lamellar body membrane	IDA	11940594 16959783
lamellar body membrane	IDA TAS	20863830
late endosome	IDA	27177387
cytoplasmic vesicle membrane	IDA	16959783 17574245 20863830
intracellular membrane-bounded organelle	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

endosome membrane [inference]

late endosome membrane [inference]

multivesicular body membrane

secretory granule membrane [inference]

lamellar body membrane

alveolar lamellar body membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane [inference]

multivesicular body membrane

secretory granule membrane [inference]

lamellar body membrane

alveolar lamellar body membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
ATP hydrolysis activity	IDA	16959783
phosphatidylcholine transfer activity	IMP	28887056
lipid transporter activity	IBA TAS
ATPase-coupled transmembrane transporter activity	IBA
ABC-type xenobiotic transporter activity	IMP	26903515

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity

phospholipid transporter activity [inference]

phosphatidylcholine transporter activity [inference]

phospholipid transfer activity [inference]

phosphatidylcholine transfer activity

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

lipid transfer activity [inference]

phospholipid transfer activity [inference]

phosphatidylcholine transfer activity

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

xenobiotic transmembrane transporter activity [inference]

ABC-type xenobiotic transporter activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

ATPase-coupled intramembrane lipid transporter activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATP-binding cassette

Functional Category

L: Replication, recombination and repair
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ATP binding
nucleotide binding

Displaying **all 3** entries
InterPro
AAA+ ATPase domain
ABC transporter-like, ATP-binding domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:12120	pulmonary alveolar proteinosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	27410		MGI:1351617	MOUSE20096
Drosophila melanogaster	33103		FB:FBgn0031170
Drosophila melanogaster	39971		FB:FBgn0036747
Caenorhabditis elegans	178559		WB:WBGene00000022
Rattus norvegicus	302973		RGD:1307174	RATNO00560
Pan troglodytes	453833	9598_0:0040e3		PANTR11500
Canis lupus familiaris	479879			CANLF16675
Bos taurus	505787			BOVIN20081
Danio rerio	564344		ZFIN:ZDB-GENE-050517-2
Macaca mulatta	696496			MACMU26082

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements