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exostosin like glycosyltransferase 2

Summary

Gene Symbol

EXTL2

Aliases

alpha-1,4-N-acteylhexosaminyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

2135

GGDB ID

gg161

HGNC

3516

mRNA

NM_001439

map

1p21

Protein

NP_001430

OMIM

602411

KEGG Gene ID

hsa:2135

PubChem

2135

Alliance of Genome Resources

HGNC:3516

Annotation

Keyword

Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Manganese
Metal-binding
Proteomics identification
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q8N8F1
F5GZK1
Q9UBQ6	Alpha-1,4-N-acetylhexosaminyltransferase EXTL2 Alpha-GalNAcT EXTL2 EXT-related protein 2 Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
heparan sulfate proteoglycan biosynthetic process	IEA
N-acetylglucosamine metabolic process	IDA	10318803
UDP-N-acetylgalactosamine metabolic process	IDA	10318803

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

sulfur compound biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

sulfur compound metabolic process [inference]

sulfur compound biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

phosphorus metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

sulfur compound biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

glucosamine-containing compound metabolic process [inference]

N-acetylglucosamine metabolic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

sulfur compound metabolic process [inference]

sulfur compound biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

phosphorus metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

sulfur compound biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	10639137
cytosol	IDA
extracellular region	IEA
endoplasmic reticulum membrane	TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
manganese ion binding	IEA
glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	IEA
alpha-1,4-N-acetylgalactosaminyltransferase activity	IDA	10318803
protein binding	IPI	32814053
glycosaminoglycan binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

acetylgalactosaminyltransferase activity [inference]

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

acetylgalactosaminyltransferase activity [inference]

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000162694

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg161

Gene Symbol

EXTL2

Reactions

Displaying **all 4** entries
Donor	Acceptor	Reference
UDP-GlcNAc	G99041PQ	10318803 11121397
UDP-GalNAc	G12916RQ	10318803
UDP-GalNAc	G99041PQ	10318803
UDP-GlcNAc	G12916RQ	10318803

Displaying **all 4** entries
Donor	Acceptor	Reference
UDP-GlcNAc	G12916RQ	10318803
UDP-GalNAc	G99041PQ	10318803
UDP-GalNAc	G12916RQ	10318803
UDP-GlcNAc	G99041PQ	10318803 11121397

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_227614	XM_227614
Mus musculus	NP_067363	NM_021388

Rhea

RHEA:16221

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.223

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 14 in total

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DO ID	Disease Name	Source
DOID:0110938	autosomal dominant osteopetrosis 2	DisGeNET
DOID:0110946	autosomal recessive osteopetrosis 7	DisGeNET
DOID:0111393	mucopolysaccharidosis type IIIC	DisGeNET
DOID:0111395	mucopolysaccharidosis type IIIA	DisGeNET
DOID:12798	mucopolysaccharidosis	DisGeNET
DOID:12799	mucopolysaccharidosis II	DisGeNET
DOID:12800	mucopolysaccharidosis VI	DisGeNET
DOID:12801	mucopolysaccharidosis III	DisGeNET DisGeNET DisGeNET
DOID:12804	mucopolysaccharidosis IV	DisGeNET
DOID:13533	osteopetrosis	DisGeNET

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Latimeria chalumnae	102348020		LATCH03566
Danio rerio	558373	ZFIN:ZDB-GENE-060929-1122	DANRE29049
Astyanax mexicanus	103035439		ASTMX06530
Electrophorus electricus	113584240		ELEEL32970
Salmo salar	100380460		SALSA19159
Salmo trutta	115170119		SALTR39725
Gadus morhua	115548361		GADMO56291
Oryzias latipes	101174221		ORYLA06921
Oreochromis niloticus	100711437		ORENI26706
Sparus aurata	115571976		SPAAU37772

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

International Collaboration

Acknowledgements