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aldhehyde dehydrogenase family 5, subfamily A1

Summary

Gene Symbol

Aldh5a1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

214579

PubChem

214579

Alliance of Genome Resources

MGI:2441982

Annotation

Keyword

Acetylation
Direct protein sequencing
Disulfide bond
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B2RS41
Q8BWF0	Aldehyde dehydrogenase family 5 member A1 NAD(+)-dependent succinic semialdehyde dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
central nervous system development	ISO
gamma-aminobutyric acid metabolic process	IMP	12067239 16504488 16647690
gamma-aminobutyric acid catabolic process	ISS
gamma-aminobutyric acid catabolic process	ISO
gamma-aminobutyric acid catabolic process	IMP	11544478 15262267

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

glutamate metabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

dicarboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

dicarboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

dicarboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

dicarboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

multicellular organismal process [inference]

post-embryonic development

developmental process [inference]

anatomical structure development [inference]

system development [inference]

central nervous system development

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrion	ISO
mitochondrion	IDA	14651853
mitochondrion	IBA
mitochondrion	HDA	14651853 18614015
synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
succinate-semialdehyde dehydrogenase (NAD+) activity	ISS
succinate-semialdehyde dehydrogenase (NAD+) activity	ISO
succinate-semialdehyde dehydrogenase (NAD+) activity	IBA
carboxylic acid binding	ISO
identical protein binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

succinate-semialdehyde dehydrogenase [NAD(P)+] activity [inference]

succinate-semialdehyde dehydrogenase (NAD+) activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 6** entries
InterPro
Aldehyde dehydrogenase domain
Aldehyde dehydrogenase, C-terminal
Aldehyde dehydrogenase, N-terminal
Aldehyde dehydrogenase, cysteine active site
Aldehyde dehydrogenase, glutamic acid active site
Aldehyde/histidinol dehydrogenase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1826	epilepsy	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 65 in total

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Species	Gene ID	Orthologous MAtrix
Octodon degus	101578427	OCTDE18388
Ficedula albicollis	101808132	FICAL02287
Chrysemys picta bellii	101945488	CHRPI01210
Ictidomys tridecemlineatus	101969246	ICTTR12241
Oreochromis niloticus	102082621	ORENI01879
Macaca fascicularis	102126652	MACFA32968
Capra hircus	102169437	CAPHI08152
Latimeria chalumnae	102345816	LATCH02059
Myotis lucifugus	102438988	MYOLU16455
Pelodiscus sinensis	102449242	PELSI09262