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aldehyde dehydrogenase 1 family member A1

Summary

Gene Symbol

ALDH1A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

216

PubChem

216

Alliance of Genome Resources

HGNC:402

Annotation

Keyword

3D-structure
Acetylation
Cell projection
Cytoplasm
Direct protein sequencing
Lipid metabolism
NAD
Nucleotide-binding
Oxidoreductase
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
V9HW83	3-deoxyglucosone dehydrogenase ALDH-E1 ALHDII Aldehyde dehydrogenase family 1 member A1 Aldehyde dehydrogenase, cytosolic Retinal dehydrogenase 1
P00352	3-deoxyglucosone dehydrogenase ALDH-E1 ALHDII Aldehyde dehydrogenase family 1 member A1 Aldehyde dehydrogenase, cytosolic Retinal dehydrogenase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cellular detoxification of aldehyde	IMP	15623782
gamma-aminobutyric acid biosynthetic process	ISS
maintenance of lens transparency	ISS
negative regulation of cold-induced thermogenesis	ISS	22561685
retinol metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

catabolic process [inference]

organic substance catabolic process [inference]

carbohydrate derivative catabolic process [inference]

amino sugar catabolic process [inference]

fructosamine catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

hormone metabolic process [inference]

retinol metabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

olefinic compound metabolic process [inference]

retinol metabolic process

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

fructosamine metabolic process [inference]

fructosamine catabolic process

amino sugar catabolic process [inference]

fructosamine catabolic process

carbohydrate derivative catabolic process [inference]

amino sugar catabolic process [inference]

fructosamine catabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organic substance catabolic process [inference]

carbohydrate derivative catabolic process [inference]

amino sugar catabolic process [inference]

fructosamine catabolic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

cellular detoxification [inference]

cellular detoxification of aldehyde

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of lens transparency

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of lens transparency

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

detoxification [inference]

cellular detoxification [inference]

cellular detoxification of aldehyde

Displaying **all 5** entries
GO Term	Evidence Code	PMID
axon	ISS
cytoplasm	TAS	2987944
synapse	ISS
cytosol	IDA TAS	12941160
extracellular exosome	HDA	19056867 19199708 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
retinal dehydrogenase activity	ISS
aminobutyraldehyde dehydrogenase activity	ISS
androgen binding	TAS	1709013
protein binding	IPI	32814053 33495566
aldehyde dehydrogenase (NAD+) activity	IDA IMP	12941160 15623782 23444097 25450233 4015840

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

retinal dehydrogenase activity

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NAD+) activity

benzaldehyde dehydrogenase [NAD(P)+] activity [inference]

benzaldehyde dehydrogenase (NAD+) activity

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

hormone binding [inference]

androgen binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aldehyde

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 6** entries
InterPro
Aldehyde dehydrogenase domain
Aldehyde dehydrogenase, C-terminal
Aldehyde dehydrogenase, N-terminal
Aldehyde dehydrogenase, cysteine active site
Aldehyde dehydrogenase, glutamic acid active site
Aldehyde/histidinol dehydrogenase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	11668	MGI:1353450
Rattus norvegicus	24188	RGD:2087
Mus musculus	26358	MGI:1347050
Drosophila melanogaster	43244	FB:FBgn0051075
Caenorhabditis elegans	175691	WB:WBGene00000107
Caenorhabditis elegans	187001	WB:WBGene00000108
Bos taurus	281615		BOVIN34457
Xenopus laevis	394296	Xenbase:XB-GENE-17345961
Xenopus laevis	397728	Xenbase:XB-GENE-987063
Ovis aries	443343		SHEEP09067

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OrthoDB (Group)

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Acknowledgements