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aldehyde dehydrogenase 2 family member

Summary

Gene Symbol

ALDH2

Organism

Homo sapiens (human)

External Links

NCBI Gene

217

HGNC

404

KEGG Gene ID

hsa:217

PubChem

217

Alliance of Genome Resources

HGNC:404

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Direct protein sequencing
Disease variant
Dwarfism
Intellectual disability
Mitochondrion
NAD
Oxidoreductase
Reference proteome
Transit peptide
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A384NPN7	ALDH class 2 ALDH-E2
P05091	ALDH class 2 ALDH-E2 ALDHI

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	TAS	8903321
alcohol metabolic process	TAS	1306115
ethanol catabolic process	IEA
nitroglycerin metabolic process	IDA	19506075
aldehyde catabolic process	IDA	20062057 27521998

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

nitroglycerin metabolic process

catabolic process [inference]

cellular catabolic process [inference]

aldehyde catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic substance catabolic process [inference]

aldehyde catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

aldehyde catabolic process

xenobiotic metabolic process [inference]

nitroglycerin metabolic process

cellular catabolic process [inference]

aldehyde catabolic process

primary metabolic process [inference]

carbohydrate metabolic process

small molecule metabolic process [inference]

alcohol metabolic process

primary alcohol metabolic process [inference]

ethanol metabolic process [inference]

ethanol catabolic process

primary alcohol catabolic process [inference]

ethanol catabolic process

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

cellular aldehyde metabolic process [inference]

aldehyde catabolic process

nitroglycerin metabolic process

organic substance catabolic process [inference]

aldehyde catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process

primary alcohol metabolic process [inference]

ethanol metabolic process [inference]

ethanol catabolic process

primary alcohol catabolic process [inference]

ethanol catabolic process

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

aldehyde catabolic process

xenobiotic metabolic process [inference]

nitroglycerin metabolic process

cellular catabolic process [inference]

aldehyde catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

regulation of dopamine biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of amine metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

regulation of dopamine biosynthetic process

regulation of serotonin biosynthetic process

regulation of primary metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

regulation of dopamine biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

regulation of dopamine biosynthetic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitochondrion	ISS
mitochondrion	HTP	34800366
mitochondrial matrix	TAS
extracellular exosome	HDA	19056867

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
aldehyde dehydrogenase (NAD+) activity	IDA	19506075 20062057 27521998 4015840
aldehyde dehydrogenase (NAD+) activity	IBA
aldehyde dehydrogenase [NAD(P)+] activity	TAS	8903321
phenylacetaldehyde dehydrogenase activity	ISS
electron transfer activity	TAS	8903321

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

aldehyde dehydrogenase [NAD(P)+] activity

aldehyde dehydrogenase (NAD+) activity

phenylacetaldehyde dehydrogenase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

carboxylesterase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 6** entries
InterPro
Aldehyde dehydrogenase domain
Aldehyde dehydrogenase, C-terminal
Aldehyde dehydrogenase, N-terminal
Aldehyde dehydrogenase, cysteine active site
Aldehyde dehydrogenase, glutamic acid active site
Aldehyde/histidinol dehydrogenase

Human Protein Atlas

ENSG00000111275

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00128

Name

aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]

References

Rhea

RHEA:25294

acetaldehyde + H₂O + NAD⁺

H⁺ + acetate + NADH

Enzyme

1.2.1.3

PMID

RHEA:16185

H₂O + an aldehyde + NAD⁺

H⁺ + a carboxylate + NADH

Enzyme

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:0070508	metabolic dysfunction and alcohol associated liver disease	Alliance of Genome Resources
DOID:0080208	metabolic dysfunction-associated steatotic liver disease	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:14018	alcoholic liver cirrhosis	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:3454	brain infarction	Alliance of Genome Resources
DOID:409	liver disease	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 3** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0001033	Facial flushing after alcohol intake
HP:0003533	Reduced acetaldehyde dehydrogenase level

Displaying 1 entry
Disease ID	Disease Name
OMIM:610251	alcohol sensitivity, acute

PubChem Disease

MedGen Diseases

Alcohol sensitivity, acute

OMIM Phenotypes

ALCOHOL SENSITIVITY, ACUTE

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002629
Gene Name: aldehyde dehydrogenase 2 family (mitochondrial)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	216	SGD:S000005982
Xenopus tropicalis	217	Xenbase:XB-GENE-490836
Saccharomyces cerevisiae S288C	219	SGD:S000005982
Saccharomyces cerevisiae S288C	220	SGD:S000005982
Saccharomyces cerevisiae S288C	8854	SGD:S000005982
Saccharomyces cerevisiae S288C	11668	SGD:S000005982
Mus musculus	11669	Xenbase:XB-GENE-490836	MOUSE46332
Saccharomyces cerevisiae S288C	24188	SGD:S000005982
Saccharomyces cerevisiae S288C	26358	SGD:S000005982
Xenopus tropicalis	29539	Xenbase:XB-GENE-490836

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements