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transmembrane channel-like gene family 8

Summary

Gene Symbol

Tmc8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

217356

PubChem

217356

Alliance of Genome Resources

MGI:2669037

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Glycoprotein
Ion channel
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B0QZP7
Q7TN58	Epidermodysplasia verruciformis protein 2 homolog
B0QZP6
B1ATC0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein stabilization	IMP	32917726
negative regulation of protein binding	ISO
regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA ISO
intracellular zinc ion homeostasis	ISS
positive regulation of apoptotic process	ISS

GO Hierarchy

biological process

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular zinc ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular zinc ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular zinc ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular zinc ion homeostasis

inorganic ion homeostasis [inference]

intracellular zinc ion homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of binding [inference]

negative regulation of protein binding

regulation of binding [inference]

regulation of protein binding [inference]

negative regulation of protein binding

negative regulation of binding [inference]

negative regulation of protein binding

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nuclear membrane	IEA ISO
Golgi apparatus	ISO
endoplasmic reticulum membrane	IEA
plasma membrane	IEA
Golgi membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32917726
mechanosensitive monoatomic ion channel activity	IBA
tumor necrosis factor binding	IEA ISO
protein sequestering activity	IEA ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

mechanosensitive monoatomic ion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

mechanosensitive monoatomic ion channel activity

gated channel activity [inference]

mechanosensitive monoatomic ion channel activity

binding [inference]

protein binding

cytokine binding [inference]

tumor necrosis factor binding

molecular sequestering activity [inference]

protein sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Transmembrane channel-like protein

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
P: Inorganic ion transport and metabolism

Displaying **all 2** entries
InterPro
TMC domain
Transmembrane channel-like protein

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:13777	epidermodysplasia verruciformis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	147138		HGNC:20474	HUMAN36613
Canis lupus familiaris	483342			CANLF18402
Bos taurus	513813			BOVIN13885
Rattus norvegicus	688276	10116_1:0037f8	RGD:1591150	RATNO03018
Danio rerio	100004462		ZFIN:ZDB-GENE-081114-2
Monodelphis domestica	100031099			MONDO13939
Callithrix jacchus	100404646			CALJA36486
Macaca mulatta	100423642			MACMU15224
Pongo abelii	100443950			PONAB12178
Ailuropoda melanoleuca	100478575			AILME13629

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements