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mannoside acetylglucosaminyltransferase 2

Summary

Gene Symbol

Mgat2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

217664

KEGG Gene ID

mmu:217664

PubChem

217664

Alliance of Genome Resources

MGI:2384966

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q921V5	Beta-1,2-N-acetylglucosaminyltransferase II GlcNAc-T II Mannoside acetylglucosaminyltransferase 2 N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
oligosaccharide biosynthetic process	IEA
protein N-linked glycosylation via asparagine	IMP ISO ISS	12417412
protein N-linked glycosylation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
Golgi apparatus	ISO
Golgi stack	IEA
Golgi membrane	IBA ISO ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
manganese ion binding	ISO ISS
alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	IBA IMP ISO ISS	12417412
protein homodimerization activity	ISO ISS
carbohydrate binding	IEA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
metal ion binding
oligosaccharide biosynthetic process
protein N-linked glycosylation
transferase activity

Displaying **all 2** entries
InterPro
N-acetylglucosaminyltransferase II
Nucleotide-diphospho-sugar transferases

KEGG BRITE Database

Orthology

K00736

Name

alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [EC:2.4.1.143]

References

2952645

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05985	2.4.1.143	G61751GZ	G39213VZ

Rhea

RHEA:12941

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.143

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070253	congenital disorder of glycosylation type IIa	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 94 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4247		HGNC:7045	HUMAN19257
Drosophila melanogaster	43563		FB:FBgn0039738
Rattus norvegicus	94273	10116_1:0025b8	RGD:620098	RATNO35945
Caenorhabditis elegans	179562		WB:WBGene00001645
Xenopus tropicalis	448439		Xenbase:XB-GENE-978789
Canis lupus familiaris	480312			CANLF17888
Macaca mulatta	706426			MACMU42610
Danio rerio	100000478		ZFIN:ZDB-GENE-070410-54	DANRE20094
Monodelphis domestica	100023862			MONDO02334
Equus caballus	100065740			HORSE16662

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements