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tissue factor pathway inhibitor

Summary

Gene Symbol

Tfpi

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

21788

PubChem

21788

Alliance of Genome Resources

MGI:1095418

Annotation

Keyword

Alternative splicing
Blood coagulation
Disulfide bond
Glycoprotein
Proteomics identification
Reference proteome
Repeat
Secreted
Serine protease inhibitor
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8BSB7
O54819	Extrinsic pathway inhibitor Lipoprotein-associated coagulation inhibitor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
negative regulation of peptidase activity	IEA
negative regulation of blood coagulation	IEA ISO
cellular response to steroid hormone stimulus	IEA
blood coagulation	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus

response to steroid hormone [inference]

cellular response to steroid hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus

response to steroid hormone [inference]

cellular response to steroid hormone stimulus

response to organic cyclic compound [inference]

response to steroid hormone [inference]

cellular response to steroid hormone stimulus

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus

response to lipid [inference]

response to steroid hormone [inference]

cellular response to steroid hormone stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to steroid hormone stimulus

cellular response to lipid [inference]

cellular response to steroid hormone stimulus

cellular response to organic cyclic compound [inference]

cellular response to steroid hormone stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of coagulation [inference]

negative regulation of blood coagulation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region
cell surface	IEA ISO
extracellular space	HDA IBA ISO	24006456
caveola	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

Displaying 1 entry
GO Term	Evidence Code	PMID
serine-type endopeptidase inhibitor activity	IBA IEA

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

tissue factor pathway inhibitor

Functional Category

H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
blood coagulation
hemostasis
peptidase inhibitor activity
serine-type endopeptidase inhibitor activity

Displaying **all 4** entries
InterPro
Pancreatic trypsin inhibitor Kunitz domain superfamily
Pancreatic trypsin inhibitor Kunitz domain
Proteinase inhibitor I2, Kunitz, conserved site
Tissue factor pathway inhibitor-like

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:5425	ovarian hyperstimulation syndrome	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of **107** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Chinchilla lanigera	102011608	34839_0:000266	CHILA00478
Macaca fascicularis	102119734		MACFA05573
Capra hircus	102185317		CAPHI21114
Pelodiscus sinensis	102457418		PELSI09074
Vicugna pacos	102536993		VICPA03374
Peromyscus maniculatus bairdii	102928752	230844_0:001947
Chlorocebus sabaeus	103217493		CHLSB01451
Carlito syrichta	103276413		CARSF06815
Ursus maritimus	103659659		URSMA01310
Nannospalax galili	103728762	1026970_0:0000da