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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
transforming growth factor, beta receptor II
Summary
- Gene Symbol
-
- Tgfbr2
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- ATP-binding
- Alternative splicing
- Apoptosis
- Cell membrane
- Differentiation
- Disulfide bond
- Glycoprotein
- Growth regulation
- Magnesium
- Manganese
- Metal-binding
- Phosphoprotein
- Receptor
- Reference proteome
- Serine/threonine-protein kinase
- Signal
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q543C0 |
|
| Q8BQS9 |
|
| Q3UG22 |
|
| Q62312 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| smoothened signaling pathway | ||
| membranous septum morphogenesis | ||
| embryonic hemopoiesis | ||
| regulation of stem cell proliferation | ||
| growth plate cartilage chondrocyte growth |
GO Hierarchy
biological process
cellular process [inference]
developmental process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of tolerance induction [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
regulation of growth [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of cellular process [inference]
positive regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cell population proliferation
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
positive regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| external side of plasma membrane | ||
| membrane | ||
| transforming growth factor beta ligand-receptor complex | ||
| receptor complex | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| SMAD binding | ||
| transforming growth factor beta receptor activity | ||
| transforming growth factor beta receptor activity, type II | ||
| type III transforming growth factor beta receptor binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- TGF-beta receptor type-2
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| SMAD binding |
| activin binding |
| activin receptor activity |
| cell differentiation |
| kinase activity |
| metal ion binding |
| nucleotide binding |
| phosphorylation |
| transferase activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050466 | Loeys-Dietz syndrome | |
| DOID:0070234 | Loeys-Dietz syndrome 2 | |
| DOID:0070273 | hereditary nonpolyposis colorectal cancer type 6 | |
| DOID:0110214 | cleft soft palate | |
| DOID:0112182 | mismatch repair cancer syndrome | |
| DOID:10283 | prostate cancer | |
| DOID:11198 | DiGeorge syndrome | |
| DOID:14323 | Marfan syndrome | |
| DOID:1793 | pancreatic cancer | |
| DOID:219 | colon cancer |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 7048 | HGNC:11773 | HUMAN69005 | ||
| 30739 | ZFIN:ZDB-GENE-980526-375 | DANRE10303 | ||
| 81810 | 10116_1:002eff | RGD:69651 | RATNO41472 | |
| 175781 | WB:WBGene00000900 | |||
| 460243 | PANTR30668 | |||
| 477039 | CANLF09015 | |||
| 494191 | SHEEP08139 | |||
| 535376 | BOVIN17184 | |||
| 703088 | MACMU30015 | |||
| 100031897 | MONDO34114 |
