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fibroblast activation protein alpha

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

2191

PubChem

2191

Alliance of Genome Resources

HGNC:3590

Annotation

Keyword

3D-structure
Alternative splicing
Angiogenesis
Apoptosis
Cell adhesion
Cell junction
Cell membrane
Cell projection
Cleavage on pair of basic residues
Cytoplasm
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Proteomics identification
Reference proteome
Secreted
Serine protease
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DLR2
Q12884	170 kDa melanoma membrane-bound gelatinase Dipeptidyl peptidase FAP Fibroblast activation protein alpha Gelatine degradation protease FAP Integral membrane serine protease Post-proline cleaving enzyme Serine integral membrane protease Surface-expressed protease

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
regulation of collagen catabolic process	IDA	10455171
endothelial cell migration	IDA	16651416
regulation of cell cycle	ISS
angiogenesis	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

cellular process [inference]

cell adhesion

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

melanocyte apoptotic process

cell population proliferation [inference]

epithelial cell proliferation [inference]

melanocyte proliferation

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

endothelial cell migration

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of collagen catabolic process

regulation of collagen metabolic process [inference]

regulation of collagen catabolic process

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cell proliferation involved in contact inhibition

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

regulation of fibrinolysis

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

regulation of fibrinolysis

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cell proliferation involved in contact inhibition

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cell proliferation involved in contact inhibition

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly [inference]

negative regulation of extracellular matrix disassembly

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of cell cycle

regulation of execution phase of apoptosis [inference]

positive regulation of execution phase of apoptosis

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

regulation of fibrinolysis

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

regulation of fibrinolysis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

regulation of fibrinolysis

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
membrane	NAS	9065413
basal part of cell	IEA
focal adhesion	HDA	21423176
ruffle membrane	NAS	10455171
plasma membrane	IBA IDA NAS	10455171 10593948

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

peptidase complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
peptidase activity	IDA	10455171 9688278
serine-type peptidase activity	IDA IMP NAS	16651416 7911242 9065413
dipeptidyl-peptidase activity	IBA IDA NAS	10593948 7911242
protein homodimerization activity	IDA	10455171
serine-type endopeptidase activity	IDA	10593948

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

exopeptidase activity [inference]

dipeptidyl-peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

exopeptidase activity [inference]

dipeptidyl-peptidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

protease binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peptidase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
dipeptidyl-peptidase activity
proteolysis
serine-type peptidase activity

Displaying **all 3** entries
InterPro
Alpha/Beta hydrolase fold
Dipeptidylpeptidase IV, N-terminal domain
Peptidase S9, prolyl oligopeptidase, catalytic domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:3748	esophagus squamous cell carcinoma	Alliance of Genome Resources
DOID:3907	lung squamous cell carcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Orthologous MAtrix
Dipodomys ordii	105994419	DIPOR00801
Equus asinus asinus	106843203	EQUAS01986
Rhinopithecus bieti	108541428	RHIBE22465
Vulpes vulpes	112916465	VULVU09042
Pseudonaja textilis	113434122	PSETE04793
Bos indicus x Bos taurus	113903304	BOBOX37985
Vombatus ursinus	114045792	VOMUR03253
Corvus moneduloides	116446572	CORMO25033
Rhinolophus ferrumequinum	117025799	RHIFE13705
Balaenoptera musculus	118898204	BALMU00261

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements