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fatty acid synthase

Summary

Gene Symbol

FASN

Aliases

3-hydroxyacyl-[acyl-carrier-protein] dehydratase
3-oxoacyl-[acyl-carrier-protein] reductase
3-oxoacyl-[acyl-carrier-protein] synthase
Acyl-[acyl-carrier-protein] hydrolase
Enoyl-[acyl-carrier-protein] reductase
FAS
SDR27X1
[Acyl-carrier-protein] S-acetyltransferase
[Acyl-carrier-protein] S-malonyltransferase
short chain dehydrogenase/reductase family 27X, member 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2194

HGNC

3594

KEGG Gene ID

hsa:2194

PubChem

2194

Alliance of Genome Resources

HGNC:3594

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Fatty acid biosynthesis
Hydrolase
Isopeptide bond
Lyase
Multifunctional enzyme
NAD
NADP
Oxidoreductase
Phosphopantetheine
Phosphoprotein
Pyridoxal phosphate
Reference proteome
S-nitrosylation
Transferase
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P49327	Type I fatty acid synthase

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
mammary gland development	IEA
fatty acid metabolic process		7835891
establishment of endothelial intestinal barrier	IEA
osteoblast differentiation	HDA	16210410
monocyte differentiation	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

fatty acid biosynthetic process

ether lipid metabolic process [inference]

ether lipid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

fatty acid biosynthetic process

ether lipid metabolic process [inference]

ether lipid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

ether metabolic process [inference]

glycerol ether metabolic process [inference]

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

fatty acid biosynthetic process

ether lipid metabolic process [inference]

ether lipid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

ether metabolic process [inference]

glycerol ether metabolic process [inference]

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

fatty acid biosynthetic process

ether lipid metabolic process [inference]

ether lipid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

granulocyte differentiation [inference]

neutrophil differentiation

mononuclear cell differentiation [inference]

monocyte differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

granulocyte differentiation [inference]

neutrophil differentiation

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial intestinal barrier

columnar/cuboidal epithelial cell development [inference]

glandular epithelial cell development

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-4

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial intestinal barrier

columnar/cuboidal epithelial cell development [inference]

glandular epithelial cell development

animal organ development [inference]

gland development [inference]

mammary gland development

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

granulocyte differentiation [inference]

neutrophil differentiation

mononuclear cell differentiation [inference]

monocyte differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

granulocyte differentiation [inference]

neutrophil differentiation

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial intestinal barrier

columnar/cuboidal epithelial cell development [inference]

glandular epithelial cell development

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

modulation by host of viral process

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to interleukin-4 [inference]

cellular response to interleukin-4

cellular response to cytokine stimulus [inference]

cellular response to interleukin-4

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-4

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-4

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-4

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GO Term	Evidence Code	PMID
glycogen granule	IEA
melanosome	IEA
cytosol	IDA TAS
cytoplasm	IBA
plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

glycogen granule

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
[acyl-carrier-protein] S-acetyltransferase activity	IDA	8962082
[acyl-carrier-protein] S-malonyltransferase activity	IEA
fatty acid synthase activity	IBA
(3R)-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	IEA
phosphopantetheine binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

acetyltransferase activity [inference]

S-acetyltransferase activity [inference]

[acyl-carrier-protein] S-acetyltransferase activity

S-acyltransferase activity [inference]

S-acetyltransferase activity [inference]

[acyl-carrier-protein] S-acetyltransferase activity

S-malonyltransferase activity [inference]

[acyl-carrier-protein] S-malonyltransferase activity

malonyltransferase activity [inference]

S-malonyltransferase activity [inference]

[acyl-carrier-protein] S-malonyltransferase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity [inference]

acyl-[acyl-carrier-protein] hydrolase activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity

(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [inference]

binding [inference]

protein binding

cell adhesion molecule binding [inference]

cadherin binding

amide binding [inference]

phosphopantetheine binding

small molecule binding [inference]

vitamin binding [inference]

phosphopantetheine binding

modified amino acid binding [inference]

phosphopantetheine binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000169710

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00665

Name

fatty acid synthase, animal type [EC:2.3.1.85]

References

2717611

Rhea

RHEA:14993

H⁺ + acetyl-CoA + malonyl-CoA + NADPH

CO₂ + CoA + a long-chain fatty acid + NADP⁺

Enzyme

2.3.1.85

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	DisGeNET DisGeNET
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050012	chikungunya	DisGeNET
DOID:0050328	congenital hypothyroidism	DisGeNET
DOID:0050431	arrhythmogenic right ventricular cardiomyopathy	DisGeNET
DOID:0050572	cone-rod dystrophy	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET
DOID:0050745	diffuse large B-cell lymphoma	DisGeNET DisGeNET
DOID:0050746	mantle cell lymphoma	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002507
Gene Name: fatty acid synthase

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	172715	WB:WBGene00009342
Drosophila melanogaster	33524	FB:FBgn0283427
Drosophila melanogaster	117361	FB:FBgn0042627
Drosophila melanogaster	3355111	FB:FBgn0287184
Callorhinchus milii	103175468		CALMI08071
Latimeria chalumnae	102352909		LATCH18314
Danio rerio	559001	ZFIN:ZDB-GENE-030131-7802
Danio rerio	100318317	ZFIN:ZDB-GENE-090603-1
Astyanax mexicanus	103030617		ASTMX12636
Ictalurus punctatus	108273998		ICTPU04846

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements