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ATP binding cassette subfamily B member 7

Summary

Gene Symbol

ABCB7

Organism

Homo sapiens (human)

External Links

NCBI Gene

PubChem

Alliance of Genome Resources

HGNC:48

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Disease variant
Mitochondrion inner membrane
Phosphoprotein
Proteomics identification
Reference proteome
Transit peptide
Transmembrane helix
Transport

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A087WW65	ATP-binding cassette sub-family B member 7, mitochondrial
O75027	ATP-binding cassette sub-family B member 7, mitochondrial ATP-binding cassette transporter 7
A0A0S2Z2Z3	ATP-binding cassette sub-family B member 7, mitochondrial

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
heme transport	IEA
intracellular iron ion homeostasis	IBA IMP ISS	30765471
iron ion transmembrane transport	IDA	17192393
negative regulation of reactive oxygen species biosynthetic process	ISS
iron-sulfur cluster export from the mitochondrion	IMP	33157103

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

iron-sulfur cluster assembly

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

iron-sulfur cluster assembly

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport

iron-sulfur cluster transmembrane transport [inference]

iron-sulfur cluster export from the mitochondrion

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

iron ion transmembrane transport

iron-sulfur cluster transmembrane transport [inference]

iron-sulfur cluster export from the mitochondrion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

metallo-sulfur cluster assembly [inference]

iron-sulfur cluster assembly

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport [inference]

iron ion transmembrane transport

iron-sulfur cluster transmembrane transport [inference]

iron-sulfur cluster export from the mitochondrion

iron coordination entity transport [inference]

heme transport

iron-sulfur cluster transmembrane transport [inference]

iron-sulfur cluster export from the mitochondrion

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport

iron-sulfur cluster transmembrane transport [inference]

iron-sulfur cluster export from the mitochondrion

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport

iron-sulfur cluster transmembrane transport [inference]

iron-sulfur cluster export from the mitochondrion

mitochondrial transport [inference]

iron-sulfur cluster export from the mitochondrion

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport

iron-sulfur cluster transmembrane transport [inference]

iron-sulfur cluster export from the mitochondrion

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

iron ion transmembrane transport

iron-sulfur cluster transmembrane transport [inference]

iron-sulfur cluster export from the mitochondrion

organic substance transport [inference]

heme transport

nitrogen compound transport [inference]

heme transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of tetrapyrrole biosynthetic process [inference]

regulation of heme biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of reactive oxygen species biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of sulfur metabolic process [inference]

positive regulation of iron-sulfur cluster assembly

positive regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of sulfur metabolic process [inference]

positive regulation of iron-sulfur cluster assembly

positive regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of tetrapyrrole biosynthetic process [inference]

regulation of heme biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of sulfur metabolic process [inference]

positive regulation of sulfur metabolic process [inference]

positive regulation of iron-sulfur cluster assembly

regulation of iron-sulfur cluster assembly [inference]

positive regulation of iron-sulfur cluster assembly

regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of tetrapyrrole biosynthetic process [inference]

regulation of heme biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of tetrapyrrole biosynthetic process [inference]

regulation of heme biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of sulfur metabolic process [inference]

positive regulation of iron-sulfur cluster assembly

positive regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of sulfur metabolic process [inference]

positive regulation of iron-sulfur cluster assembly

positive regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of cellular component organization [inference]

positive regulation of iron-sulfur cluster assembly

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of sulfur metabolic process [inference]

positive regulation of iron-sulfur cluster assembly

positive regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of tetrapyrrole biosynthetic process [inference]

regulation of heme biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of sulfur metabolic process [inference]

positive regulation of sulfur metabolic process [inference]

positive regulation of iron-sulfur cluster assembly

regulation of iron-sulfur cluster assembly [inference]

positive regulation of iron-sulfur cluster assembly

regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of tetrapyrrole biosynthetic process [inference]

regulation of heme biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

regulation of cellular component biogenesis [inference]

regulation of iron-sulfur cluster assembly [inference]

positive regulation of iron-sulfur cluster assembly

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of sulfur metabolic process [inference]

positive regulation of iron-sulfur cluster assembly

positive regulation of tetrapyrrole metabolic process [inference]

positive regulation of tetrapyrrole biosynthetic process [inference]

positive regulation of heme biosynthetic process

positive regulation of cellular component organization [inference]

positive regulation of iron-sulfur cluster assembly

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of iron-sulfur cluster assembly

regulation of iron-sulfur cluster assembly [inference]

positive regulation of iron-sulfur cluster assembly

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	IBA IDA TAS
mitochondrion	HTP IDA	22655043 34800366

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	25063848 30765471
ATP hydrolysis activity	IEA
identical protein binding	IPI	30765471
ABC-type iron-sulfur cluster transporter activity	IMP	33157103
heme transmembrane transporter activity	TAS	9621516

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

heme transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type iron-sulfur cluster transporter activity

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type iron-sulfur cluster transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ABC

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050554	X-linked sideroblastic anemia with ataxia	Alliance of Genome Resources
DOID:8955	sideroblastic anemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	11306		MGI:109533	MOUSE64575
Drosophila melanogaster	38193		FB:FBgn0035244
Caenorhabditis elegans	171807		WB:WBGene00022281
Rattus norvegicus	302395		RGD:1303086	RATNO44767
Pan troglodytes	473672	9598_0:005560		PANTR46321
Canis lupus familiaris	491967			CANLF19902
Danio rerio	566515		ZFIN:ZDB-GENE-050517-10	DANRE07550
Macaca mulatta	704034			MACMU48204
Saccharomyces cerevisiae S288C	855347		SGD:S000004916
Monodelphis domestica	100010563			MONDO00193

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements