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fibrillin 1

Summary

Gene Symbol

FBN1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2200

PubChem

2200

Alliance of Genome Resources

HGNC:3603

Annotation

Keyword

3D-structure
Aortic aneurysm
Calcium
Direct protein sequencing
Disease variant
Disulfide bond
Dwarfism
EGF-like domain
Extracellular matrix
Glycoprotein
Heparin-binding
Hormone
Phosphoprotein
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P35555

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
sequestering of BMP in extracellular matrix	ISS
anatomical structure morphogenesis	IBA
cell adhesion mediated by integrin	IDA	12807887 17158881
heart development	IMP	15781745
negative regulation of osteoclast differentiation	IDA	24039232

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell adhesion [inference]

cell adhesion mediated by integrin

signal transduction

intracellular signal transduction [inference]

protein kinase A signaling

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

developmental process [inference]

anatomical structure morphogenesis

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic eye morphogenesis

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

embryonic morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic eye morphogenesis

anatomical structure development [inference]

lung alveolus development

animal organ development [inference]

kidney development [inference]

metanephros development

sensory organ development [inference]

eye development [inference]

camera-type eye development

heart development

system development [inference]

skeletal system development

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

response to peptide hormone [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to transforming growth factor beta stimulus

response to transforming growth factor beta [inference]

cellular response to transforming growth factor beta stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to growth factor stimulus [inference]

cellular response to transforming growth factor beta stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

response to peptide hormone [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

response to peptide [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

response to peptide [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin-like growth factor stimulus

localization [inference]

maintenance of location [inference]

maintenance of protein location [inference]

maintenance of protein location in extracellular region [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast development [inference]

negative regulation of osteoclast development

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of response to extracellular stimulus [inference]

positive regulation of response to nutrient levels [inference]

positive regulation of response to food [inference]

positive regulation of appetite

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of multicellular organismal process [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of response to extracellular stimulus [inference]

positive regulation of response to nutrient levels [inference]

positive regulation of response to food [inference]

positive regulation of appetite

regulation of response to extracellular stimulus [inference]

positive regulation of response to extracellular stimulus [inference]

positive regulation of response to nutrient levels [inference]

positive regulation of response to food [inference]

positive regulation of appetite

regulation of response to nutrient levels [inference]

regulation of response to food [inference]

positive regulation of response to food [inference]

positive regulation of appetite

positive regulation of response to nutrient levels [inference]

positive regulation of response to food [inference]

positive regulation of appetite

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of response to extracellular stimulus [inference]

positive regulation of response to nutrient levels [inference]

positive regulation of response to food [inference]

positive regulation of appetite

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast development [inference]

negative regulation of osteoclast development

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast development [inference]

negative regulation of osteoclast development

regulation of cellular process [inference]

signal transduction

intracellular signal transduction [inference]

protein kinase A signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast development [inference]

negative regulation of osteoclast development

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway [inference]

sequestering of TGFbeta in extracellular matrix

negative regulation of BMP signaling pathway [inference]

sequestering of BMP in extracellular matrix

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of osteoclast development

regulation of osteoclast development [inference]

negative regulation of osteoclast development

regulation of biological quality [inference]

regulation of appetite [inference]

positive regulation of appetite

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of protein kinase A activity

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GO Term	Evidence Code	PMID
extracellular matrix	IBA IDA	3536967
microfibril	IDA	10424889 12429738 1860873 22355679 3536967 7534784 8120105
collagen-containing extracellular matrix	HDA	20551380 23658023 23979707 25037231 27559042 28327460 28675934
endoplasmic reticulum lumen	TAS
basement membrane	IDA	3536967

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

basement membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

microfibril

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GO Term	Evidence Code	PMID
protein binding	IPI	12429738 15131124 15165854 15790312 17293099 18339631 19349279 19570982 21402694 22355679 24039232 25034023 26601954 32296183
integrin binding	IPI	12807887 15062093 17158881
heparin binding	IDA	11461921
protein-containing complex binding	IPI	15062093
extracellular matrix structural constituent	IBA IDA RCA	20551380 23979707 25037231 27559042 28327460 28675934 3536967

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

extracellular matrix constituent conferring elasticity

structural molecule activity conferring elasticity [inference]

extracellular matrix constituent conferring elasticity

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

receptor ligand activity [inference]

hormone activity

identical protein binding

cell adhesion molecule binding [inference]

integrin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding

integrin binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Kinase

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation

Displaying **all 2** entries
InterPro
Protein kinase domain
Protein kinase-like domain superfamily

Disease

Disease Ontology

Displaying entries **1 - 10** of 20 in total

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DO ID	Disease Name	Source
DOID:0050475	Weill-Marchesani syndrome	Alliance of Genome Resources
DOID:0060218	CREST syndrome	Alliance of Genome Resources
DOID:0060249	scoliosis	Alliance of Genome Resources
DOID:0111150	autosomal dominant isolated ectopia lentis 1	Alliance of Genome Resources
DOID:0111243	acromicric dysplasia	Alliance of Genome Resources
DOID:0111561	stiff skin syndrome	Alliance of Genome Resources
DOID:0111726	geleophysic dysplasia 2	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:114	heart disease	Alliance of Genome Resources
DOID:14323	Marfan syndrome	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14118		MGI:95489	MOUSE33303
Rattus norvegicus	83727		RGD:620908	RATNO27489
Caenorhabditis elegans	176076		WB:WBGene00022816
Bos taurus	281154			BOVIN01390
Sus scrofa	414836			PIGXX14379
Pan troglodytes	453411	9598_0:003de0		PANTR10267
Canis lupus familiaris	478293			CANLF12494
Macaca mulatta	714451			MACMU42275
Meleagris gallopavo	723984			MELGA03128
Monodelphis domestica	100025769			MONDO02463

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements