fructose-bisphosphatase 1

Summary
Gene Symbol
  • FBP1
Organism
Homo sapiens (human)
External Links
NCBI Gene
2203
HGNC
3606
KEGG Gene ID
hsa:2203
PubChem
2203
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Acetylation
  • Allosteric enzyme
  • Carbohydrate metabolism
  • Direct protein sequencing
  • Disease variant
  • Gluconeogenesis
  • Hydrolase
  • Magnesium
  • Metal-binding
  • Nucleotide-binding
  • Phosphoprotein
  • Reference proteome
Proteins
Displaying all 2 entries
UniProt Protein Name
Q2TU34
  • D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
  • Liver FBPase
P09467
  • D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
  • Liver FBPase
Gene Ontology (GO)
GO Hierarchy
GO Hierarchy
Human Protein Atlas
ENSG00000165140

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K03841
Name
fructose-1,6-bisphosphatase I [EC:3.1.3.11]
References
Disease
Disease Ontology
Displaying entries 61 - 70 of 106 in total
DO ID Disease Name Source
DOID:3620 central nervous system cancer
DOID:3650 lactic acidosis
DOID:3683 lung benign neoplasm
DOID:3702 cervical adenocarcinoma
DOID:3904 bronchus carcinoma
DOID:3905 lung carcinoma
DOID:3908 lung non-small cell carcinoma
DOID:4001 ovarian carcinoma
DOID:4015 sarcomatoid carcinoma
DOID:4362 cervical cancer
The Human Phenotype Ontology
Displaying entries 11 - 20 of 39 in total
HPO ID HPO Term
HP:0001649 Tachycardia
HP:0001942 Metabolic acidosis
HP:0001943 Hypoglycemia
HP:0001945 Fever
HP:0001946 Ketosis
HP:0001998 Neonatal hypoglycemia
HP:0002013 Vomiting
HP:0002014 Diarrhea
HP:0002094 Dyspnea
HP:0002098 Respiratory distress
Displaying all 2 entries
Disease ID Disease Name
ORPHA:348
  • fructose-1,6-bisphosphatase deficiency
OMIM:229700
  • fructose-1,6-bisphosphatase deficiency

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024