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Fc epsilon receptor II

Summary

Gene Symbol

FCER2

Aliases

C-type lectin domain family 4 member J
CD23
CLEC4J
FCErII
Fc epsilon RII
FcepsilonRII

Organism

Homo sapiens (human)

External Links

NCBI Gene

2208

HGNC

3612

KEGG Gene ID

hsa:2208

PubChem

2208

Alliance of Genome Resources

HGNC:3612

Annotation

Keyword

3D-structure
Calcium
Cell membrane
Direct protein sequencing
Disulfide bond
IgE-binding protein
Lectin
Metal-binding
Palmitate
Proteoglycan
Proteomics identification
Receptor
Reference proteome
Repeat
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P06734	BLAST-2 C-type lectin domain family 4 member J Fc-epsilon-RII Immunoglobulin E-binding factor Lymphocyte IgE receptor
K3W4U1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

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GO Term	Evidence Code	PMID
positive regulation of nitric-oxide synthase biosynthetic process	IDA	7544003
Fc receptor-mediated immune complex endocytosis	IDA	2167225
Fc-epsilon receptor signaling pathway	IEA
macrophage activation	IDA	7544003
immune response	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response

antigen processing and presentation [inference]

B cell antigen processing and presentation

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

Fc receptor-mediated immune complex endocytosis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

biological process involved in interspecies interaction between organisms [inference]

modulation of process of another organism [inference]

regulation of killing of cells of another organism [inference]

positive regulation of killing of cells of another organism

response to stimulus [inference]

immune response

localization [inference]

protein-containing complex localization [inference]

Fc receptor-mediated immune complex endocytosis

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

Fc receptor-mediated immune complex endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

Fc receptor-mediated immune complex endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of humoral immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of nitric-oxide synthase biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of nitric-oxide synthase biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of nitric-oxide synthase biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cell killing [inference]

positive regulation of killing of cells of another organism

positive regulation of programmed cell death [inference]

positive regulation of killing of cells of another organism

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of humoral immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of nitric-oxide synthase biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of cell killing [inference]

positive regulation of cell killing [inference]

positive regulation of killing of cells of another organism

regulation of killing of cells of another organism [inference]

positive regulation of killing of cells of another organism

regulation of programmed cell death [inference]

positive regulation of programmed cell death [inference]

positive regulation of killing of cells of another organism

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cell killing [inference]

positive regulation of killing of cells of another organism

positive regulation of programmed cell death [inference]

positive regulation of killing of cells of another organism

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of nitric-oxide synthase activity [inference]

positive regulation of nitric-oxide synthase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
plasma membrane	IDA TAS	7544003
extracellular exosome	HDA	20458337

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16172256 25416956
integrin binding	TAS	2529542
IgE binding	IDA	16172256
metal ion binding	IEA
protease binding	IPI	12777399

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

protease binding

cell adhesion molecule binding [inference]

integrin binding

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

immunoglobulin binding [inference]

IgE binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

immunoglobulin receptor activity [inference]

IgE receptor activity [inference]

low-affinity IgE receptor activity

pattern recognition receptor activity

immune receptor activity [inference]

immunoglobulin receptor activity [inference]

IgE receptor activity [inference]

low-affinity IgE receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

C-type lectin

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
C-type lectin fold
C-type lectin-like/link domain superfamily
C-type lectin-like

Human Protein Atlas

ENSG00000104921

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)