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Fc epsilon receptor II

Summary

Gene Symbol

FCER2

Aliases

C-type lectin domain family 4 member J
CD23
CLEC4J
FCErII
Fc epsilon RII
FcepsilonRII

Organism

Homo sapiens (human)

External Links

NCBI Gene

2208

HGNC

3612

KEGG Gene ID

hsa:2208

PubChem

2208

Alliance of Genome Resources

HGNC:3612

Annotation

Keyword

3D-structure
Calcium
Cell membrane
Direct protein sequencing
Disulfide bond
IgE-binding protein
Lectin
Metal-binding
Palmitate
Proteoglycan
Proteomics identification
Receptor
Reference proteome
Repeat
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P06734	BLAST-2 C-type lectin domain family 4 member J Fc-epsilon-RII Immunoglobulin E-binding factor Lymphocyte IgE receptor
K3W4U1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
positive regulation of killing of cells of another organism	IDA	7544003
macrophage activation	IDA	7544003
immune response	IBA
Fc-epsilon receptor signaling pathway	IEA
B cell antigen processing and presentation	IDA	2167225

GO Hierarchy

biological process

immune system process [inference]

immune response

antigen processing and presentation [inference]

B cell antigen processing and presentation

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

Fc receptor-mediated immune complex endocytosis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

biological process involved in interspecies interaction between organisms

modulation of process of another organism [inference]

regulation of killing of cells of another organism [inference]

positive regulation of killing of cells of another organism

response to stimulus [inference]

immune response

localization [inference]

protein-containing complex localization [inference]

Fc receptor-mediated immune complex endocytosis

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

Fc receptor-mediated immune complex endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

Fc receptor-mediated immune complex endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of humoral immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of nitric-oxide synthase biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of nitric-oxide synthase biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of nitric-oxide synthase biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cell killing [inference]

positive regulation of killing of cells of another organism

positive regulation of programmed cell death [inference]

positive regulation of killing of cells of another organism

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of humoral immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of humoral immune response mediated by circulating immunoglobulin [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

positive regulation of humoral immune response [inference]

positive regulation of humoral immune response mediated by circulating immunoglobulin

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway [inference]

Fc-epsilon receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of nitric-oxide synthase biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

regulation of cell killing [inference]

positive regulation of cell killing [inference]

positive regulation of killing of cells of another organism

regulation of killing of cells of another organism [inference]

positive regulation of killing of cells of another organism

regulation of programmed cell death [inference]

positive regulation of programmed cell death [inference]

positive regulation of killing of cells of another organism

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of cell killing [inference]

positive regulation of killing of cells of another organism

positive regulation of programmed cell death [inference]

positive regulation of killing of cells of another organism

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of nitric-oxide synthase activity [inference]

positive regulation of nitric-oxide synthase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
plasma membrane	IDA TAS	7544003
extracellular exosome	HDA	20458337

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
low-affinity IgE receptor activity	IDA	7544003
integrin binding		2529542
metal ion binding	IEA
carbohydrate binding	IBA
protein binding	IPI	16172256 25416956

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

protease binding

cell adhesion molecule binding [inference]

integrin binding

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

immunoglobulin binding [inference]

IgE binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

immunoglobulin receptor activity [inference]

IgE receptor activity [inference]

low-affinity IgE receptor activity

immune receptor activity [inference]

immunoglobulin receptor activity [inference]

IgE receptor activity [inference]

low-affinity IgE receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000104921

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K06468

Name

low affinity immunoglobulin epsilon Fc receptor

References

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050589	inflammatory bowel disease	DisGeNET
DOID:0050597	intestinal schistosomiasis	DisGeNET
DOID:0050746	mantle cell lymphoma	DisGeNET
DOID:0050747	obsolete lymphoplasmacytic lymphoma	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0050873	follicular lymphoma	DisGeNET
DOID:0050909	extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue	DisGeNET
DOID:0060022	CD40 ligand deficiency	DisGeNET
DOID:0060023	immunodeficiency with hyper IgM type 3	DisGeNET
DOID:0060058	lymphoma	DisGeNET

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	186111	WB:WBGene00018692
Caenorhabditis elegans	186903	WB:WBGene00019328
Drosophila melanogaster	53516	FB:FBgn0040096
Drosophila melanogaster	3346221	FB:FBgn0053533
Ornithorhynchus anatinus	103168129		ORNAN29091
Sarcophilus harrisii	100927399		SARHA00803
Callithrix jacchus	100409349		CALJA24506
Cercocebus atys	105589139		CERAT44030
Macaca mulatta	708980		MACMU19892
Macaca nemestrina	105484364		MACNE12375

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements