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aldehyde dehydrogenase 3 family member B1

Summary

Gene Symbol

ALDH3B1

Aliases

aldehyde dehydrogenase 3B1
aldehyde dehydrogenase 7

Organism

Homo sapiens (human)

External Links

NCBI Gene

221

HGNC

410

KEGG Gene ID

hsa:221

PubChem

221

Alliance of Genome Resources

HGNC:410

Annotation

Keyword

Acetylation
Alternative splicing
Cell membrane
Lipid metabolism
Methylation
NAD
Oxidoreductase
Palmitate
Prenylation
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P43353	Aldehyde dehydrogenase 7
A0A087X2D4

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
ethanol catabolic process	IEA
response to oxidative stress	IDA	20699116
cellular response to oxidative stress	IDA	20699116
alcohol metabolic process		7828891
lipid metabolic process		7828891

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

aldehyde catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

aldehyde catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process

aldehyde catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

aldehyde catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

primary metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

small molecule metabolic process [inference]

alcohol metabolic process

primary alcohol metabolic process [inference]

ethanol metabolic process [inference]

ethanol catabolic process

primary alcohol catabolic process [inference]

ethanol catabolic process

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process

aldehyde catabolic process

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

aldehyde catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process

primary alcohol metabolic process [inference]

ethanol metabolic process [inference]

ethanol catabolic process

primary alcohol catabolic process [inference]

ethanol catabolic process

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

primary alcohol catabolic process [inference]

ethanol catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process

aldehyde catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

aldehyde catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

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GO Term	Evidence Code	PMID
vesicle	HDA	19190083
cytosol	IEA
cytoplasm	IBA IDA	20699116
plasma membrane
secretory granule membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

specific granule membrane

bounding membrane of organelle [inference]

secretory granule membrane

specific granule membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
aldehyde dehydrogenase [NAD(P)+] activity	IDA TAS	20699116
benzaldehyde dehydrogenase (NADP+) activity	IEA
aldehyde dehydrogenase (NAD+) activity	IBA
3-chloroallyl aldehyde dehydrogenase activity	IBA
protein binding	IPI	25416956 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

3-chloroallyl aldehyde dehydrogenase activity

aldehyde dehydrogenase [NAD(P)+] activity

aldehyde dehydrogenase (NAD+) activity

benzaldehyde dehydrogenase (NAD+) activity

benzaldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NADP+) activity [inference]

benzaldehyde dehydrogenase (NADP+) activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000006534

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00129

Name

aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]

References

Rhea

RHEA:11840

H₂O + benzaldehyde + NAD⁺

H⁺ + benzoate + NADH

Enzyme

1.2.1.28

PMID

19297586

RHEA:21660

H₂O + benzaldehyde + NADP⁺

H⁺ + benzoate + NADPH

Enzyme

1.2.1.7

PMID

RHEA:11888

H₂O + an aldehyde + NADP⁺

H⁺ + a carboxylate + NADPH

Enzyme

PMID

RHEA:16185

H₂O + an aldehyde + NAD⁺

H⁺ + a carboxylate + NADH

Enzyme

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:1229	paranoid schizophrenia	DisGeNET
DOID:14501	Sjogren-Larsson syndrome	Alliance of Genome Resources
DOID:4450	renal cell carcinoma	DisGeNET
DOID:4451	renal carcinoma	DisGeNET
DOID:4464	collecting duct carcinoma	DisGeNET
DOID:4465	papillary renal cell carcinoma	DisGeNET
DOID:4467	clear cell renal cell carcinoma	DisGeNET
DOID:4471	chromophobe renal cell carcinoma	DisGeNET
DOID:4473	sarcomatoid renal cell carcinoma	DisGeNET
DOID:5419	schizophrenia	DisGeNET

Ortholog

Displaying entries **1 - 10** of 52 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178680	WB:WBGene00000111
Caenorhabditis elegans	179026	WB:WBGene00000110
Drosophila melanogaster	45398	FB:FBgn0010548
Danio rerio	282559	ZFIN:ZDB-GENE-021120-3	DANRE32165
Astyanax mexicanus	103038420		ASTMX18972
Ictalurus punctatus	108258475		ICTPU25554
Electrophorus electricus	113574356		ELEEL13827
Salmo trutta	115171597		SALTR94615
Salmo trutta	115204627		SALTR25658
Oryzias latipes	101158531		ORYLA17196

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements