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MIRAGE
Fc gamma receptor IIb
Summary
- Gene Symbol
-
- FCGR2B
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Chromosomal rearrangement
- Disulfide bond
- Glycoprotein
- Host-virus interaction
- IgG-binding protein
- Immunoglobulin domain
- Phosphoprotein
- Proto-oncogene
- Receptor
- Reference proteome
- Repeat
- Signal
- Systemic lupus erythematosus
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P31994 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| antibody-dependent cellular cytotoxicity | ||
| negative regulation of type I hypersensitivity | ||
| negative regulation of antibody-dependent cellular cytotoxicity | ||
| negative regulation of cytokine production | ||
| immune effector process |
GO Hierarchy
- regulation of immune complex clearance by monocytes and macrophages
- regulation of innate immune response
- regulation of innate immune response
biological process
immune system process [inference]
cellular process [inference]
multicellular organismal process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of antigen processing and presentation [inference]
negative regulation of immune system process [inference]
regulation of leukocyte activation [inference]
regulation of immune effector process [inference]
negative regulation of immune effector process [inference]
regulation of leukocyte mediated immunity [inference]
regulation of immune response [inference]
regulation of adaptive immune response
negative regulation of adaptive immune response [inference]
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]
regulation of inflammatory response to antigenic stimulus [inference]
negative regulation of immune response
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of response to stimulus [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
regulation of response to external stimulus [inference]
negative regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of adaptive immune response
negative regulation of adaptive immune response [inference]
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]
regulation of inflammatory response to antigenic stimulus [inference]
negative regulation of immune response
regulation of response to stress [inference]
regulation of defense response [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of vesicle-mediated transport [inference]
regulation of cellular response to stress [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| plasma membrane | ||
| external side of plasma membrane | ||
| external side of plasma membrane | ||
| dendritic spine |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| amyloid-beta binding | ||
| amyloid-beta binding | ||
| protein binding | ||
| IgG receptor activity | ||
| low-affinity IgG receptor activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Low affinity immunoglobulin gamma Fc region receptor II
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cell surface receptor signaling pathway |
| InterPro |
|---|
| Immunoglobulin-like domain |
| Immunoglobulin-like fold |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1037 | lymphoid leukemia | |
| DOID:12365 | malaria | |
| DOID:2921 | glomerulonephritis | |
| DOID:8924 | autoimmune thrombocytopenic purpura | |
| DOID:9074 | systemic lupus erythematosus |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 102186356 | CAPHI22912 | ||
| 103658249 | URSMA13720 | ||
| 105498217 | MACNE23711 | ||
| 106831114 | EQUAS32397 | ||
| 113883646 | BOBOX06709 |
