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tubulin, alpha 1A

Summary

Gene Symbol

Tuba1a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22142

PubChem

22142

Alliance of Genome Resources

MGI:98869

Annotation

Keyword

3D-structure
Acetylation
Cytoskeleton
Direct protein sequencing
GTP-binding
Hydrolase
Isopeptide bond
Magnesium
Metal-binding
Methylation
Microtubule
Nitration
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P68369	Alpha-tubulin 1 Alpha-tubulin isotype M-alpha-1 Tubulin alpha-1 chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 38 in total

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GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IMP	21875651 22101068 28687665
microtubule cytoskeleton organization	IBA
mitotic cell cycle	IBA
neuron migration	IMP	17218254 21041996 21875651 28687665 31386652
startle response	IMP	21875651

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

microtubule polymerization or depolymerization [inference]

microtubule polymerization

microtubule-based movement [inference]

cilium movement [inference]

cilium movement involved in cell motility [inference]

flagellated sperm motility

transport along microtubule [inference]

organelle transport along microtubule

microtubule organizing center organization [inference]

centrosome cycle

cell cycle [inference]

mitotic cell cycle

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cell cycle process [inference]

centrosome cycle

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

pyramidal neuron differentiation

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

cell migration [inference]

neuron migration

sperm motility [inference]

flagellated sperm motility

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

microtubule polymerization or depolymerization [inference]

microtubule polymerization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

neuron projection arborization

microtubule organizing center organization [inference]

centrosome cycle

cell junction organization [inference]

synapse organization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

supramolecular fiber organization [inference]

microtubule polymerization

reproductive process [inference]

sperm motility [inference]

flagellated sperm motility

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

neuromuscular process [inference]

startle response

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

locomotory behavior

visual behavior [inference]

visual learning

adult behavior

adult locomotory behavior

exploration behavior [inference]

locomotory exploration behavior

motor behavior

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

homeostasis of number of cells within a tissue

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

homeostasis of number of cells within a tissue

developmental process [inference]

anatomical structure morphogenesis [inference]

cerebellar cortex morphogenesis

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

neuron projection arborization

forebrain morphogenesis

anatomical structure development [inference]

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

pyramidal neuron differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

homeostasis of number of cells within a tissue

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

homeostasis of number of cells within a tissue

response to stimulus [inference]

response to external stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

response to mechanical stimulus

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

response to L-glutamate

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

response to L-glutamate

response to cytokine [inference]

response to tumor necrosis factor

response to calcium ion [inference]

cellular response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

response to L-glutamate

response to oxygen-containing compound [inference]

response to amino acid [inference]

response to L-glutamate

response to calcium ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

response to salt [inference]

response to calcium ion [inference]

cellular response to calcium ion

response to L-glutamate

cellular response to salt [inference]

cellular response to calcium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

microtubule-based transport [inference]

transport along microtubule [inference]

organelle transport along microtubule

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule

establishment of organelle localization [inference]

organelle transport along microtubule

organelle localization [inference]

establishment of organelle localization [inference]

organelle transport along microtubule

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

regulation of cellular component organization [inference]

regulation of synapse organization

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
condensed chromosome	IDA	24244602
cytoplasm	IBA
cytosol	IDA	19056362
microtubule	ISO
microtubule	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse

neuromuscular junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

condensed chromosome

cytoskeleton [inference]

microtubule cytoskeleton

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

condensed chromosome

cytoskeleton [inference]

microtubule cytoskeleton

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

cytoplasmic microtubule

axonemal microtubule

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GO Term	Evidence Code	PMID
structural constituent of cytoskeleton	IBA
structural constituent of cytoskeleton	IEA
protein binding	IPI	19893491 20037577 24244602
GTP binding	IMP	17218254
GTP binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding

protein dimerization activity [inference]

protein heterodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tubulin A

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
GTP binding
cytoskeleton organization
hydrolase activity
microtubule cytoskeleton organization
microtubule-based process
nucleotide binding
structural constituent of cytoskeleton

Displaying **all 9** entries
InterPro
Alpha tubulin
Tubulin, C-terminal
Tubulin, conserved site
Tubulin/FtsZ, 2-layer sandwich domain
Tubulin/FtsZ, C-terminal
Tubulin/FtsZ, GTPase domain superfamily
Tubulin/FtsZ, GTPase domain
Tubulin/FtsZ-like, C-terminal domain
Tubulin

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050453	lissencephaly	Alliance of Genome Resources
DOID:2490	congenital nervous system abnormality	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	7277	SGD:S000004593
Homo sapiens	7846	Xenbase:XB-GENE-492543	HUMAN12441
Homo sapiens	10376	Xenbase:XB-GENE-22063827	HUMAN12435
Xenopus tropicalis	22142	Xenbase:XB-GENE-492543
Xenopus tropicalis	22143	Xenbase:XB-GENE-22063827
Saccharomyces cerevisiae S288C	22144	SGD:S000004593
Saccharomyces cerevisiae S288C	22145	SGD:S000004593
Saccharomyces cerevisiae S288C	22146	SGD:S000004593
Saccharomyces cerevisiae S288C	22147	SGD:S000004593
Saccharomyces cerevisiae S288C	53857	SGD:S000004593

GlyTouCan

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements