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tubulin, beta 5 class I

Summary

Gene Symbol

Tubb5

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22154

PubChem

22154

Alliance of Genome Resources

MGI:107812

Annotation

Keyword

Acetylation
Cytoskeleton
Direct protein sequencing
GTP-binding
Isopeptide bond
Magnesium
Metal-binding
Methylation
Microtubule
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P99024

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
regulation of synapse organization	IDA IMP	24833723
odontoblast differentiation	IEA
microtubule cytoskeleton organization	IBA
mitotic cell cycle	IBA
microtubule-based process	IDA NAS	15121885 3782288

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process

microtubule cytoskeleton organization

spindle organization [inference]

spindle assembly

cell cycle [inference]

mitotic cell cycle

cell cycle process [inference]

spindle organization [inference]

spindle assembly

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

neuroepithelial cell differentiation [inference]

odontoblast differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

spindle organization [inference]

spindle assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

neuroepithelial cell differentiation [inference]

odontoblast differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cellular component organization [inference]

regulation of synapse organization

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
microtubule	IBA IDA ISO	15121885
tubulin complex	NAS	3782288
protein-containing complex	ISO
membrane raft	IEA ISO
cell body	IEA ISO

GO Hierarchy

cellular component

protein-containing complex

tubulin complex

cellular anatomical entity [inference]

membrane [inference]

membrane microdomain [inference]

membrane raft

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

nuclear envelope lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

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GO Term	Evidence Code	PMID
GTPase activity	IEA
protein-containing complex binding	IEA ISO
MHC class I protein binding	IEA ISO
metal ion binding	IEA
structural constituent of cytoskeleton	IBA IDA	15121885

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

MHC protein binding [inference]

MHC class I protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Tubulin

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
GTP binding
cytoskeleton organization
microtubule cytoskeleton organization
microtubule-based process
nucleotide binding
structural constituent of cytoskeleton

Displaying **all 10** entries
InterPro
Beta tubulin, autoregulation binding site
Beta tubulin
Tubulin, C-terminal
Tubulin, conserved site
Tubulin/FtsZ, 2-layer sandwich domain
Tubulin/FtsZ, C-terminal
Tubulin/FtsZ, GTPase domain superfamily
Tubulin/FtsZ, GTPase domain
Tubulin/FtsZ-like, C-terminal domain
Tubulin

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0050997	cerebellar ataxia, mental retardation and dysequlibrium syndrome	Alliance of Genome Resources
DOID:0060260	ptosis	Alliance of Genome Resources
DOID:0090132	complex cortical dysplasia with other brain malformations 7	Alliance of Genome Resources
DOID:0090136	complex cortical dysplasia with other brain malformations 6	Alliance of Genome Resources
DOID:0112227	tubulinopathy	Alliance of Genome Resources
DOID:0112242	congenital symmetric circumferential skin creases 1	Alliance of Genome Resources
DOID:10907	microcephaly	Alliance of Genome Resources
DOID:13934	facial paralysis	Alliance of Genome Resources
DOID:14452	hypokalemic periodic paralysis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **175** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	29213	10116_1:003292
Rattus norvegicus	29214	10116_1:00533b	RGD:628596	RATNO21783
Drosophila melanogaster	37238		FB:FBgn0284243
Caenorhabditis elegans	175461		WB:WBGene00000248
Caenorhabditis elegans	176501		WB:WBGene00006536
Homo sapiens	203068		HGNC:20778	HUMAN83756
Rattus norvegicus	296554	10116_1:001684
Danio rerio	386701		ZFIN:ZDB-GENE-031110-4
Xenopus tropicalis	448742		Xenbase:XB-GENE-482185
Pan troglodytes	471960			PANTR37629

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Summary

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Annotation

OrthoDB (Group)

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Acknowledgements