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lysine demethylase 1B

Summary

Gene Symbol

KDM1B

Organism

Homo sapiens (human)

External Links

NCBI Gene

221656

PubChem

221656

Alliance of Genome Resources

HGNC:21577

Annotation

Keyword

3D-structure
Alternative splicing
Chromatin regulator
Chromosome
Developmental protein
FAD
Nucleus
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Repressor
Transcription regulation
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8NB78	Flavin-containing amine oxidase domain-containing protein 1 Lysine-specific histone demethylase 1B
H0Y6H0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
chromatin remodeling
epigenetic programing of female pronucleus	IEA
transcription initiation-coupled chromatin remodeling	IDA	30970244
genomic imprinting	ISS	19727073

GO Hierarchy

biological process

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

genomic imprinting

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

epigenetic regulation of gene expression [inference]

post-fertilization epigenetic regulation of gene expression [inference]

epigenetic programming in the zygotic pronuclei [inference]

epigenetic programing of female pronucleus

genomic imprinting

transcription initiation-coupled chromatin remodeling

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

genomic imprinting

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

epigenetic regulation of gene expression [inference]

post-fertilization epigenetic regulation of gene expression [inference]

epigenetic programming in the zygotic pronuclei [inference]

epigenetic programing of female pronucleus

genomic imprinting

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

epigenetic regulation of gene expression [inference]

post-fertilization epigenetic regulation of gene expression [inference]

epigenetic programming in the zygotic pronuclei [inference]

epigenetic programing of female pronucleus

genomic imprinting

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

epigenetic regulation of gene expression [inference]

post-fertilization epigenetic regulation of gene expression [inference]

epigenetic programming in the zygotic pronuclei [inference]

epigenetic programing of female pronucleus

genomic imprinting

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

epigenetic regulation of gene expression [inference]

post-fertilization epigenetic regulation of gene expression [inference]

epigenetic programming in the zygotic pronuclei [inference]

epigenetic programing of female pronucleus

genomic imprinting

Displaying **all 5** entries
GO Term	Evidence Code	PMID
chromatin	IDA	30970244
nucleosome	IDA	23260659
nucleus	ISS	19727073
nucleoplasm	TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
chromatin binding
protein binding	IPI	23260659 28514442 33961781
zinc ion binding	IDA	23260659 23266887
oxidoreductase activity	IBA
histone demethylase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

FAD-dependent H3K4me/H3K4me3 demethylase activity

demethylase activity [inference]

protein demethylase activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K4 demethylase activity [inference]

FAD-dependent H3K4me/H3K4me3 demethylase activity

catalytic activity, acting on a protein [inference]

protein demethylase activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K4 demethylase activity [inference]

FAD-dependent H3K4me/H3K4me3 demethylase activity

histone modifying activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K4 demethylase activity [inference]

FAD-dependent H3K4me/H3K4me3 demethylase activity

binding [inference]

protein binding

histone binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

FAD binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

FAD binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

FAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Histone lysine-specific demethylase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
flavin adenine dinucleotide binding
oxidoreductase activity
sarcosine oxidase activity

Displaying **all 3** entries
InterPro
FAD dependent oxidoreductase
FAD/NAD(P)-binding domain superfamily
MTOX family

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	178934	SGD:S000004622
Mus musculus	218214		MOUSE10582
Xenopus tropicalis	221656	Xenbase:XB-GENE-982183
Rattus norvegicus	306819		RATNO12947
Pan troglodytes	462459		PANTR37312
Canis lupus familiaris	478733		CANLF13758
Bos taurus	513667		BOVIN19152
Macaca mulatta	704663		MACMU34906
Taeniopygia guttata	100225070		TAEGU16848
Oryctolagus cuniculus	100340794		RABIT14439