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Fc gamma receptor and transporter

Summary

Gene Symbol

FCGRT

Organism

Homo sapiens (human)

External Links

NCBI Gene

2217

PubChem

2217

Alliance of Genome Resources

HGNC:3621

Annotation

Keyword

3D-structure
Cell membrane
Direct protein sequencing
Disulfide bond
Endosome
Glycoprotein
IgG-binding protein
Immunoglobulin domain
Phosphoprotein
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P55899	IgG Fc fragment receptor transporter alpha chain Neonatal Fc receptor
A0A024QZI2	IgG Fc fragment receptor transporter alpha chain Neonatal Fc receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor	NAS	7964511
immune response	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

vesicle-mediated transport [inference]

transcytosis [inference]

immunoglobulin transcytosis in epithelial cells [inference]

IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor

multicellular organismal process [inference]

transcytosis [inference]

immunoglobulin transcytosis in epithelial cells [inference]

IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor

response to stimulus [inference]

immune response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

transcytosis [inference]

immunoglobulin transcytosis in epithelial cells [inference]

IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor

Displaying **all 3** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
endosome membrane	IEA
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
beta-2-microglobulin binding	IBA
protein binding	IPI	32296183
IgG binding	IDA	7964511
peptide antigen binding	ISS

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

peptide antigen binding

protein binding

beta-2-microglobulin binding

amide binding [inference]

peptide binding [inference]

peptide antigen binding

protein-containing complex binding [inference]

immunoglobulin binding [inference]

IgG binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

T-cell surface glycoprotein CD1b

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
antigen processing and presentation, endogenous lipid antigen via MHC class Ib
antigen processing and presentation, exogenous lipid antigen via MHC class Ib
endogenous lipid antigen binding
exogenous lipid antigen binding
immune response
lipopeptide binding
positive regulation of T cell mediated cytotoxicity

Displaying **all 7** entries
InterPro
Immunoglobulin C1-set
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
MHC class I-like antigen recognition-like superfamily
MHC class I-like antigen recognition-like
MHC classes I/II-like antigen recognition protein

Ortholog

Displaying entries **1 - 10** of 46 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14132		MGI:103017	MOUSE53818
Rattus norvegicus	29558		RGD:61811	RATNO18312
Xenopus tropicalis	447976		Xenbase:XB-GENE-484711
Pan troglodytes	456208	9598_0:004f9e		PANTR18929
Canis lupus familiaris	476414			CANLF00801
Danio rerio	556341		ZFIN:ZDB-GENE-070424-4
Macaca mulatta	718859			MACMU00223
Monodelphis domestica	100030352			MONDO22823
Ovis aries	100144766			SHEEP05673
Equus caballus	100147583			HORSE01175