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farnesyl diphosphate synthase

Summary

Gene Symbol

FDPS

Aliases

farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

2224

HGNC

3631

KEGG Gene ID

hsa:2224

PubChem

2224

Alliance of Genome Resources

HGNC:3631

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cholesterol biosynthesis
Cytoplasm
Disease variant
Host-virus interaction
Hydroxylation
Isoprene biosynthesis
Magnesium
Metal-binding
Proteomics identification
Reference proteome
Transferase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A087X090	(2E,6E)-farnesyl diphosphate synthase Dimethylallyltranstransferase Farnesyl diphosphate synthase Geranyltranstransferase
P14324	(2E,6E)-farnesyl diphosphate synthase Dimethylallyltranstransferase Farnesyl diphosphate synthase Geranyltranstransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
farnesyl diphosphate biosynthetic process	IBA IEA
cholesterol biosynthetic process	IEA
geranyl diphosphate biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

terpenoid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

terpenoid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

terpenoid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

terpenoid biosynthetic process [inference]

geranyl diphosphate metabolic process [inference]

geranyl diphosphate biosynthetic process

farnesyl diphosphate metabolic process [inference]

farnesyl diphosphate biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
peroxisome	IDA	17198737
nucleoplasm	IDA
mitochondrial matrix	IDA	17198737
cytosol	IDA TAS	17198737
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16713569 32296183 32814053
metal ion binding	IEA
geranyltranstransferase activity	IBA
RNA binding	HDA	22658674
dimethylallyltranstransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

prenyltransferase activity [inference]

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Farnesyl

Functional Category

H: Coenzyme transport and metabolism
I: Lipid transport and metabolism

Displaying **all 4** entries
Gene Ontology
dimethylallyltranstransferase activity
farnesyl diphosphate biosynthetic process
geranyltranstransferase activity
transferase activity

Displaying **all 4** entries
InterPro
Farnesyl pyrophosphate synthase-like
Isoprenoid synthase domain superfamily
Polyprenyl synthetase, conserved site
Polyprenyl synthetase

KEGG BRITE Database

Orthology

K00787

Name

farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]

References

Rhea

RHEA:22408

isopentenyl diphosphate + dimethylallyl diphosphate

diphosphate + (2E)-geranyl diphosphate

Enzyme

2.5.1.1

PMID

RHEA:19361

isopentenyl diphosphate + (2E)-geranyl diphosphate

(2E,6E)-farnesyl diphosphate + diphosphate

Enzyme

2.5.1.10

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3805	porokeratosis	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 8** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000989	Pruritus
HP:0000992	Cutaneous photosensitivity
HP:0002860	Squamous cell carcinoma
HP:0003596	Middle age onset
HP:0003621	Juvenile onset
HP:0011462	Young adult onset
HP:0200044	Porokeratosis

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:616631	porokeratosis 9, multiple types
ORPHA:79152	disseminated superficial actinic porokeratosis

PubChem Disease

MedGen Diseases

Porokeratosis 9, multiple types

OMIM Phenotypes

POROKERATOSIS 9, MULTIPLE TYPES; POROK9

KEGG Diseases

Porokeratosis

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001166
Gene Name: farnesyl diphosphate synthase

Ortholog

Displaying entries **31 - 40** of 72 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Gorilla gorilla gorilla	101130805	9595_0:000041	GORGO19150
Oryzias latipes	101157393		ORYLA05756
Tursiops truncatus	101331919		TURTR13544
Octodon degus	101560436		OCTDE06854
Jaculus jaculus	101606613		JACJA18986
Jaculus jaculus	101610267		JACJA18986
Mustela putorius furo	101693108		MUSPF02210
Chrysemys picta bellii	101941324		CHRPI17136
Ictidomys tridecemlineatus	101971426		ICTTR01389
Chinchilla lanigera	102007154		CHILA23338

GlyTouCan

GlyComb

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements