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very low density lipoprotein receptor

Summary

Gene Symbol

Vldlr

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22359

PubChem

22359

Alliance of Genome Resources

MGI:98935

Annotation

Keyword

Cholesterol metabolism
Coated pit
Disulfide bond
EGF-like domain
Endocytosis
Glycoprotein
Isopeptide bond
Lipid transport
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation
VLDL

Proteins

Displaying **all 4** entries
UniProt	Protein Name
F8WGI9
Q91YY0
Q3UVX6
P98156

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
dendrite morphogenesis	IMP	18778775
positive regulation of protein kinase activity	IGI	12526740
receptor-mediated endocytosis	IEA ISO
regulation of synapse assembly	IDA IMP	25644714
lipid transport	IEA

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

reelin-mediated signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

glycoprotein transport

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

multicellular organismal process [inference]

plasma lipoprotein particle clearance [inference]

very-low-density lipoprotein particle clearance

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure development [inference]

ventral spinal cord development

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to stress [inference]

cellular response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

glycoprotein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

organic substance transport [inference]

lipid transport

protein transport [inference]

glycoprotein transport

carbohydrate derivative transport [inference]

glycoprotein transport

nitrogen compound transport [inference]

protein transport [inference]

glycoprotein transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

establishment of protein localization [inference]

protein transport [inference]

glycoprotein transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

glycoprotein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

positive regulation of developmental process [inference]

positive regulation of dendrite development

regulation of developmental process [inference]

regulation of dendrite development [inference]

positive regulation of dendrite development

positive regulation of developmental process [inference]

positive regulation of dendrite development

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

reelin-mediated signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

regulation of dendrite development [inference]

positive regulation of dendrite development

regulation of synapse organization [inference]

regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
glutamatergic synapse	IDA	25644714
very-low-density lipoprotein particle	IEA
synapse	IDA	25644714
plasma membrane	IBA
extracellular space	IDA	15950758

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

triglyceride-rich plasma lipoprotein particle [inference]

very-low-density lipoprotein particle

receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

clathrin-coated pit

cell junction [inference]

synapse

glutamatergic synapse

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
reelin receptor activity	IDA IGI IMP	10571241 18778775
calcium ion binding	IEA
protein binding	IPI	15249135
apolipoprotein binding	IBA IEA ISO
very-low-density lipoprotein particle binding	IEA ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

very-low-density lipoprotein particle binding

cargo receptor activity

lipoprotein particle receptor activity [inference]

very-low-density lipoprotein particle receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

reelin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

very low-density lipoprotein receptor

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription

Displaying **all 5** entries
Gene Ontology
apolipoprotein binding
calcium ion binding
cholesterol metabolic process
lipid transport
steroid metabolic process

Displaying entries **1 - 10** of 11 in total

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InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
LDL receptor-like superfamily
LDLR class B repeat
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
NOTCH1 EGF-like calcium-binding domain

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0110014	age related macular degeneration 1	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1184	nephrotic syndrome	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources
DOID:1307	dementia	Alliance of Genome Resources
DOID:1312	focal segmental glomerulosclerosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **116** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7436		HGNC:12698	HUMAN96313
Rattus norvegicus	25696	10116_1:000550	RGD:3963	RATNO20476
Drosophila melanogaster	43105		FB:FBgn0051092
Caenorhabditis elegans	174116		WB:WBGene00020481
Bos taurus	282123			BOVIN34388
Danio rerio	393897		ZFIN:ZDB-GENE-040426-803	DANRE00230
Pan troglodytes	464967			PANTR43561
Canis lupus familiaris	476336			CANLF00460
Macaca mulatta	574284			MACMU12056
Xenopus tropicalis	733485		Xenbase:XB-GENE-971958

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements