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Von Willebrand factor

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22371

PubChem

22371

Alliance of Genome Resources

MGI:98941

Annotation

Keyword

3D-structure
Alternative splicing
Blood coagulation
Cell adhesion
Cleavage on pair of basic residues
Disulfide bond
Extracellular matrix
Glycoprotein
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
E9QPU1
Q8CIZ8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
activation of blood coagulation via clotting cascade	IDA	30573509
placenta development	IMP	7854452
hemostasis	IMP ISO ISS TAS	11212329 9689113
cell adhesion	ISO ISS
platelet activation	IMP ISO ISS	10930441 17380206 21037087

GO Hierarchy

biological process

cellular process [inference]

cell activation [inference]

platelet activation

cell adhesion

cell-substrate adhesion

multicellular organismal process [inference]

cell activation [inference]

platelet activation

coagulation [inference]

blood coagulation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

placenta development

gland development [inference]

liver development

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of hemostasis [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of wound healing [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of hemostasis [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of hemostasis [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular matrix	IBA
external side of plasma membrane	IDA	8562500
collagen-containing extracellular matrix	HDA ISO ISS	22159717 28071719
extracellular region	ISO ISS
Weibel-Palade body	IDA ISO ISS	30573509

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI ISS	18281502
integrin binding	ISO ISS
extracellular matrix structural constituent	RCA	22159717 28071719
protein-folding chaperone binding	ISO ISS
protease binding	ISO ISS

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

protease binding

identical protein binding

cell adhesion molecule binding [inference]

integrin binding

protein-folding chaperone binding

protein-containing complex binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

von Willebrand factor

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
P: Inorganic ion transport and metabolism

Displaying **all 6** entries
Gene Ontology
blood coagulation
cell-substrate adhesion
collagen binding
hemostasis
identical protein binding
platelet activation

Displaying **all 10** entries
InterPro
Cystine knot, C-terminal
Serine protease inhibitor-like superfamily
Trypsin Inhibitor-like, cysteine rich domain
VWF/SSPO/Zonadhesin-like, cysteine-rich domain
VWFC domain
Von Willebrand factor
von Willebrand factor A-like domain superfamily
von Willebrand factor, VWA N-terminal domain
von Willebrand factor, type A
von Willebrand factor, type D domain

Disease

Disease Ontology

Displaying entries **1 - 10** of 27 in total

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DO ID	Disease Name	Source
DOID:0060224	atrial fibrillation	Alliance of Genome Resources
DOID:0060573	von Willebrand's disease 1	Alliance of Genome Resources
DOID:0060574	von Willebrand's disease 2	Alliance of Genome Resources
DOID:0111054	von Willebrand's disease 3	Alliance of Genome Resources
DOID:10159	osteonecrosis	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10941	intracranial aneurysm	Alliance of Genome Resources
DOID:12531	von Willebrand's disease	Alliance of Genome Resources
DOID:1312	focal segmental glomerulosclerosis	Alliance of Genome Resources
DOID:13241	Behcet's disease	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7450		HGNC:12726	HUMAN10590
Rattus norvegicus	116669	10116_1:0018b3	RGD:621759	RATNO30628
Bos taurus	280958			BOVIN30485
Sus scrofa	399543			PIGXX26354
Canis lupus familiaris	399544			CANLF11162
Pan troglodytes	451773			PANTR04911
Felis catus	493760			FELCA17417
Danio rerio	570643		ZFIN:ZDB-GENE-070103-1	DANRE13497
Oryctolagus cuniculus	100009165			RABIT12299
Equus caballus	100059472			HORSE37453