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wingless-type MMTV integration site family, member 2B

Summary

Gene Symbol

Wnt2b

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22414

PubChem

22414

Alliance of Genome Resources

MGI:1261834

Annotation

Keyword

Developmental protein
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Reference proteome
Signal
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
O70283	Protein Wnt-13

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
neuron differentiation	IBA
positive regulation of branching involved in ureteric bud morphogenesis	IDA	11507767
forebrain regionalization	IEP	15164427
male gonad development	IEA
hematopoietic stem cell proliferation	IEA ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

mesenchymal-epithelial cell signaling

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

signal transduction

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

cell population proliferation [inference]

stem cell proliferation [inference]

hematopoietic stem cell proliferation

cellular developmental process [inference]

cell differentiation [inference]

cell fate commitment

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

forebrain regionalization

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure morphogenesis [inference]

animal organ morphogenesis

developmental induction [inference]

organ induction [inference]

lung induction

anatomical structure development [inference]

animal organ development [inference]

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

cellular developmental process [inference]

cell differentiation [inference]

cell fate commitment

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

mesenchymal-epithelial cell signaling

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

positive regulation of morphogenesis of an epithelium [inference]

positive regulation of branching involved in ureteric bud morphogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of branching involved in ureteric bud morphogenesis

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of morphogenesis of a branching structure [inference]

regulation of branching involved in lung morphogenesis [inference]

lung induction

regulation of branching involved in ureteric bud morphogenesis [inference]

positive regulation of branching involved in ureteric bud morphogenesis

regulation of morphogenesis of an epithelium [inference]

regulation of branching involved in lung morphogenesis [inference]

lung induction

regulation of branching involved in ureteric bud morphogenesis [inference]

positive regulation of branching involved in ureteric bud morphogenesis

positive regulation of morphogenesis of an epithelium [inference]

positive regulation of branching involved in ureteric bud morphogenesis

regulation of animal organ morphogenesis [inference]

regulation of animal organ formation [inference]

organ induction [inference]

lung induction

regulation of branching involved in ureteric bud morphogenesis [inference]

positive regulation of branching involved in ureteric bud morphogenesis

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

positive regulation of developmental process [inference]

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

positive regulation of morphogenesis of an epithelium [inference]

positive regulation of branching involved in ureteric bud morphogenesis

regulation of kidney development [inference]

regulation of branching involved in ureteric bud morphogenesis [inference]

positive regulation of branching involved in ureteric bud morphogenesis

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

lung induction

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of branching involved in ureteric bud morphogenesis

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

regulation of morphogenesis of a branching structure [inference]

regulation of branching involved in lung morphogenesis [inference]

lung induction

regulation of branching involved in ureteric bud morphogenesis [inference]

positive regulation of branching involved in ureteric bud morphogenesis

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

lung induction

Displaying **all 3** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IEA ISO
extracellular region	IEA
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21856951
signaling receptor binding	TAS	9889131
frizzled binding	IBA
cytokine activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

G protein-coupled receptor binding [inference]

frizzled binding

receptor ligand activity [inference]

cytokine activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Wnt

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
canonical Wnt signaling pathway
cell fate commitment
cytokine activity
neuron differentiation
signaling receptor binding
system development

Displaying **all 4** entries
InterPro
Wnt protein, conserved site
Wnt, C-terminal domain
Wnt-2 protein
Wnt

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060774	congenital diarrhea	Alliance of Genome Resources
DOID:1911	endodermal sinus tumor	Alliance of Genome Resources
DOID:3307	teratoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **117** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7482		HGNC:12781	HUMAN51332
Rattus norvegicus	116466	10116_1:00101e	RGD:69346	RATNO22749
Caenorhabditis elegans	173399		WB:WBGene00000857
Caenorhabditis elegans	177870		WB:WBGene00000858
Danio rerio	359837		ZFIN:ZDB-GENE-030717-2
Bos taurus	445420			BOVIN26250
Pan troglodytes	457103			PANTR22019
Danio rerio	556087		ZFIN:ZDB-GENE-060824-6	DANRE45639
Macaca mulatta	705773			MACMU24870
Monodelphis domestica	100033140			MONDO14332