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zona pellucida glycoprotein 2

Summary

Gene Symbol

Zp2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22787

PubChem

22787

Alliance of Genome Resources

MGI:99214

Annotation

Keyword

3D-structure
Cell membrane
Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Extracellular matrix
Fertilization
Glycoprotein
Proteomics identification
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P20239	Zona pellucida glycoprotein 2 Zona pellucida protein A
Q3UX44	Zona pellucida glycoprotein 2 Zona pellucida protein A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
binding of sperm to zona pellucida	IDA	11739644 22472438
binding of sperm to zona pellucida	IBA
prevention of polyspermy	IDA	22472438
prevention of polyspermy	IBA

GO Hierarchy

biological process

cellular process [inference]

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

reproductive process [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

prevention of polyspermy

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of reproductive process [inference]

negative regulation of fertilization [inference]

prevention of polyspermy

regulation of reproductive process [inference]

regulation of fertilization [inference]

negative regulation of fertilization [inference]

prevention of polyspermy

negative regulation of reproductive process [inference]

negative regulation of fertilization [inference]

prevention of polyspermy

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
multivesicular body	IDA	17047254
endoplasmic reticulum	IDA	17047254
plasma membrane	IDA	17047254
egg coat	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11739644
acrosin binding	ISO
acrosin binding	IBA
acrosin binding	IEA
structural constituent of egg coat	ISS

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent [inference]

structural constituent of egg coat

binding [inference]

protein binding

enzyme binding [inference]

acrosin binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

zona pellucida sperm-binding protein 2

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 4** entries
Gene Ontology
binding of sperm to zona pellucida
prevention of polyspermy
single fertilization
structural constituent of egg coat

Displaying **all 3** entries
InterPro
Zona pellucida domain, chordate-type
Zona pellucida domain
Zona pellucida, ZP-C domain

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7783	Xenbase:XB-GENE-976172	HUMAN27129
Xenopus tropicalis	22787	Xenbase:XB-GENE-976172
Rattus norvegicus	81828	Xenbase:XB-GENE-976172	RATNO21160
Sus scrofa	396846		PIGXX20795
Xenopus tropicalis	398089	Xenbase:XB-GENE-976172
Canis lupus familiaris	403988		CANLF16504
Pan troglodytes	453979		PANTR11912
Felis catus	493977		FELCA34971
Macaca mulatta	697458		MACMU27418
Oryctolagus cuniculus	100009069		RABIT11202