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neuroligin 4 Y-linked

Summary

Gene Symbol

NLGN4Y

Organism

Homo sapiens (human)

External Links

NCBI Gene

22829

PubChem

22829

Alliance of Genome Resources

HGNC:15529

Annotation

Keyword

Alternative splicing
Cell adhesion
Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Postsynaptic cell membrane
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DHI3
Q8NFZ3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
presynapse assembly	TAS	21838267
presynaptic membrane assembly	IBA
neuron cell-cell adhesion	IBA TAS	18923512
learning	IMP	18628683
vocalization behavior	IMP	18628683

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cell adhesion [inference]

cell-cell adhesion [inference]

neuron cell-cell adhesion

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

membrane assembly [inference]

presynapse assembly

membrane organization [inference]

postsynaptic membrane organization [inference]

postsynaptic membrane assembly

membrane assembly [inference]

presynaptic membrane organization [inference]

presynaptic membrane assembly

presynapse organization [inference]

presynapse assembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

import into cell [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
membrane	TAS	21838267
postsynaptic density membrane	IEA
presynapse	IEA
postsynaptic specialization membrane	IBA
asymmetric, glutamatergic, excitatory synapse	TAS	21838267

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane

postsynaptic density membrane

cell junction [inference]

synapse

excitatory synapse [inference]

asymmetric, glutamatergic, excitatory synapse

inhibitory synapse [inference]

symmetric, GABA-ergic, inhibitory synapse

glutamatergic synapse [inference]

asymmetric, glutamatergic, excitatory synapse

GABA-ergic synapse [inference]

symmetric, GABA-ergic, inhibitory synapse

neuron to neuron synapse [inference]

asymmetric synapse [inference]

asymmetric, glutamatergic, excitatory synapse

symmetric synapse [inference]

symmetric, GABA-ergic, inhibitory synapse

presynapse

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	17292328
neurexin family protein binding	IBA
signaling receptor activity	IBA
scaffold protein binding	IPI	17292328
cell adhesion molecule binding	TAS	18923512

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

neurexin family protein binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

neuroligin-4, X-linked

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
chemical synaptic transmission
modulation of chemical synaptic transmission
neuron cell-cell adhesion
postsynaptic membrane assembly
presynapse assembly
presynaptic membrane assembly

Displaying **all 4** entries
InterPro
Alpha/Beta hydrolase fold
Carboxylesterase type B, conserved site
Carboxylesterase, type B
Neuroligin

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 35 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	33962		FB:FBgn0031866
Drosophila melanogaster	37854		FB:FBgn0034972
Drosophila melanogaster	40912		FB:FBgn0083963
Drosophila melanogaster	40913		FB:FBgn0051146
Drosophila melanogaster	42402		FB:FBgn0083975
Caenorhabditis elegans	181484		WB:WBGene00006412
Pan troglodytes	449030	9598_0:005920		PANTR47342
Pan troglodytes	465474	9598_0:005551
Danio rerio	561122		ZFIN:ZDB-GENE-100309-2	DANRE16884
Mus musculus	100113365		MGI:3775191

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements