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dolichol kinase

Summary

Gene Symbol

DOLK

Aliases

DK1
KIAA1094
dolichol kinase 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

22845

HGNC

23406

KEGG Gene ID

hsa:22845

PubChem

22845

Alliance of Genome Resources

HGNC:23406

Annotation

Keyword

Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Kinase
Lipid metabolism
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UPQ8	Transmembrane protein 15
A0A0S2Z597

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
dolichyl monophosphate biosynthetic process	IBA IDA	12213788 16923818
dolichyl diphosphate biosynthetic process

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IBA IDA TAS	16923818

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
dolichol kinase activity	IBA IDA TAS	12213788 16923818
protein binding	IPI	25416956 26871637 28514442 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

dolichol kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

dolichol kinase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00902

Name

dolichol kinase [EC:2.7.1.108]

References

12213788

Rhea

CTP

H⁺ + CDP

Enzyme

2.7.1.108

PMID

Disease

Disease Ontology

Displaying entries **31 - 40** of 58 in total

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DO ID	Disease Name	Source
DOID:0110449	dilated cardiomyopathy 1M	DisGeNET
DOID:0110450	dilated cardiomyopathy 1II	DisGeNET
DOID:0110451	dilated cardiomyopathy 1O	DisGeNET
DOID:0110452	dilated cardiomyopathy 1T	DisGeNET
DOID:0110453	dilated cardiomyopathy 1EE	DisGeNET
DOID:0110454	dilated cardiomyopathy 1S	DisGeNET
DOID:0110455	dilated cardiomyopathy 1U	DisGeNET
DOID:0110456	dilated cardiomyopathy 1R	DisGeNET
DOID:0110457	dilated cardiomyopathy 1Y	DisGeNET
DOID:0110458	dilated cardiomyopathy 1BB	DisGeNET

The Human Phenotype Ontology

Displaying entries **11 - 20** of 55 in total

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HPO ID	HPO Term
HP:0000962	Hyperkeratosis
HP:0000969	Edema
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001252	Hypotonia
HP:0001270	Motor delay
HP:0001344	Absent speech
HP:0001508	Failure to thrive
HP:0001522	Death in infancy
HP:0001596	Alopecia

Displaying **all 3** entries
Disease ID	Disease Name
ORPHA:154	dilated cardiomyopathy 1KK obsolete familial isolated dilated cardiomyopathy
ORPHA:91131	DK1-congenital disorder of glycosylation
OMIM:610768	DK1-congenital disorder of glycosylation

PubChem Disease

GHR Health Conditions

DOLK-congenital disorder of glycosylation

MedGen Diseases

DK1-congenital disorder of glycosylation

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Im; CDG1M

KEGG Diseases

Congenital disorders of glycosylation type I

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006686
Gene Name: dolichol kinase

Ortholog

Displaying entries **81 - 86** of 86 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	855026	SGD:S000004615
Cyprinus carpio carpio	109058815		CYPCA133355
Cyprinus carpio carpio	109064360		CYPCA98179
Nannospalax galili	103727983		NANGA03998
Corvus moneduloides	116454517		CORMO10533
Strigops habroptila	115616965		STRHB17942

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024