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vasohibin 1

Summary

Gene Symbol

VASH1

Organism

Homo sapiens (human)

External Links

NCBI Gene

22846

PubChem

22846

Alliance of Genome Resources

HGNC:19964

Annotation

Keyword

3D-structure
Alternative splicing
Carboxypeptidase
Cytoplasm
Growth arrest
Reference proteome
Secreted
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q7L8A9	Tubulin carboxypeptidase 1 Tyrosine carboxypeptidase 1 Vasohibin-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
response to wounding	IDA	23056314
proteolysis	IDA	29146869
negative regulation of blood vessel endothelial cell migration	IDA	15467828
negative regulation of angiogenesis	IDA IGI	15467828 20133819
labyrinthine layer blood vessel development	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

blood vessel development [inference]

placenta blood vessel development [inference]

labyrinthine layer blood vessel development

animal organ development [inference]

embryonic organ development [inference]

labyrinthine layer blood vessel development

response to stimulus [inference]

response to stress [inference]

response to wounding

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular senescence

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of lymphangiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis

negative regulation of angiogenesis

regulation of lymphangiogenesis [inference]

negative regulation of lymphangiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of lymphangiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular senescence

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of cell cycle

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	15467828
extracellular space	IDA	15467828 20133819 20736312
apical part of cell	IDA	20736312
cytoplasm	IBA IDA	15467828

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

apical part of cell

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 29146869 31171830 31235910 31270470
actin binding	IDA	29146869
metallocarboxypeptidase activity	IDA IMP	29146869 31171830 31235911
tubulin-tyrosine carboxypeptidase	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

tubulin-tyrosine carboxypeptidase

exopeptidase activity [inference]

carboxypeptidase activity [inference]

metallocarboxypeptidase activity

tubulin-tyrosine carboxypeptidase

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

tubulin-tyrosine carboxypeptidase

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

tubulin-tyrosine carboxypeptidase

exopeptidase activity [inference]

carboxypeptidase activity [inference]

metallocarboxypeptidase activity

tubulin-tyrosine carboxypeptidase

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

tubulin-tyrosine carboxypeptidase

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Vasohibin

Functional Category

E: Amino acid transport and metabolism
H: Coenzyme transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of angiogenesis

Displaying 1 entry
InterPro
Tubulinyl-Tyr carboxypeptidase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10762	portal hypertension	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 98 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	238328		MGI:2442543	MOUSE08011
Pan troglodytes	467514	9598_0:003bd2		PANTR09223
Canis lupus familiaris	490799			CANLF18110
Rattus norvegicus	503052		RGD:1564082	RATNO35896
Bos taurus	615419			BOVIN01770
Macaca mulatta	703906			MACMU40812
Danio rerio	100001748		ZFIN:ZDB-GENE-111020-11	DANRE13137
Monodelphis domestica	100022684			MONDO02705
Equus caballus	100051887			HORSE22843
Ornithorhynchus anatinus	100076763			ORNAN13149