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arylsulfatase G

Summary

Gene Symbol

ARSG

Aliases

KIAA1001

Organism

Homo sapiens (human)

External Links

NCBI Gene

22901

HGNC

24102

KEGG Gene ID

hsa:22901

PubChem

22901

Alliance of Genome Resources

HGNC:24102

Annotation

Keyword

Calcium
Disease variant
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Metal-binding
Reference proteome
Retinitis pigmentosa
Signal
Usher syndrome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96EG1	N-sulfoglucosamine-3-sulfatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
retina development in camera-type eye	IEA
lysosome organization	IEA
sulfur compound metabolic process	IDA	18283100
homeostasis of number of cells	IEA
gene expression	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

sulfur compound metabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cellular metabolic process [inference]

sulfur compound metabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells

developmental process [inference]

anatomical structure development [inference]

retina development in camera-type eye

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	TAS
lysosome	IDA	18283100
endoplasmic reticulum	IDA	12461688
extracellular space	IDA	18283100

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
arylsulfatase activity	IBA IDA IMP TAS	12461688 16174644 18283100 29300381
metal ion binding	IEA
N-sulfoglucosamine-3-sulfatase activity	IDA	22689975

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

sulfuric ester hydrolase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

arylsulfatase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
hydrolase activity
sulfuric ester hydrolase activity

Displaying **all 3** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
Sulfatase, N-terminal
Sulfatase, conserved site

KEGG BRITE Database

Orthology

K12381

Name

arylsulfatase G [EC:3.1.6.-]

References

18283100

Rhea

RHEA:17261

an aryl sulfate + H₂O

H⁺ + sulfate + a phenol

Enzyme

3.1.6.1

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050439	Usher syndrome	Alliance of Genome Resources
DOID:12798	mucopolysaccharidosis	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 24 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000375	Abnormal cochlea morphology
HP:0000407	Sensorineural hearing impairment
HP:0000408	Progressive sensorineural hearing impairment
HP:0000483	Astigmatism
HP:0000512	Abnormal electroretinogram
HP:0000518	Cataract
HP:0000546	Retinal degeneration
HP:0000572	Visual loss
HP:0000575	Scotoma

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:618144	Usher syndrome, type 4
ORPHA:231183	Usher syndrome type 3 retinitis pigmentosa-deafness syndrome

PubChem Disease

MedGen Diseases

Usher syndrome, type 4

OMIM Phenotypes

USHER SYNDROME, TYPE IV; USH4

KEGG Diseases

Usher syndrome

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP005434
Gene Name: arylsulfatase G

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	74008		MGI:1921258	MOUSE06542
Rattus norvegicus	303631		RGD:1306571	RATNO01668
Pan troglodytes	454844	9598_0:0044b8		PANTR15275
Canis lupus familiaris	480460			CANLF18590
Bos taurus	513067			BOVIN14114
Danio rerio	564790		ZFIN:ZDB-GENE-060503-154	DANRE03873
Macaca mulatta	718912			MACMU16168
Monodelphis domestica	100029210			MONDO09856
Equus caballus	100062864			HORSE04345
Taeniopygia guttata	100232718			TAEGU07274

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements