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Guidelines

MIRAGE

DExH-box helicase 30

Summary

Gene Symbol

DHX30

Organism

Homo sapiens (human)

External Links

NCBI Gene

22907

PubChem

22907

Alliance of Genome Resources

HGNC:16716

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Disease variant
Helicase
Intellectual disability
Mitochondrion nucleoid
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Ribosome biogenesis

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q7L2E3	DEAH box protein 30
H7BXY3	DEAH box protein 30

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
central nervous system development	ISS
mitochondrial large ribosomal subunit assembly	IMP	25683715

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

ribosomal large subunit assembly [inference]

mitochondrial large ribosomal subunit assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

ribosomal large subunit assembly [inference]

mitochondrial large ribosomal subunit assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

ribosomal large subunit assembly [inference]

mitochondrial large ribosomal subunit assembly

developmental process [inference]

anatomical structure development [inference]

system development [inference]

central nervous system development

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	IBA
cytoplasm	IDA	29100085
cytoplasm	IBA
mitochondrion	IDA	29100085
mitochondrion	HTP	34800366

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoid [inference]

mitochondrial nucleoid

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

supramolecular complex [inference]

ribonucleoprotein granule

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
G-quadruplex RNA binding	IBA
DNA helicase activity	IBA
chromatin binding	IDA	18063578
RNA binding	IDA	29100085
RNA binding	HDA	22658674 22681889

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity

catalytic activity, acting on RNA [inference]

RNA helicase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity

ATP-dependent activity, acting on RNA [inference]

RNA helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

atp-dependent rna helicase

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
V: Defense mechanisms

Displaying **all 2** entries
Gene Ontology
ATP binding
hydrolase activity

Displaying **all 5** entries
InterPro
DEAD/DEAH box helicase domain
DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
Helicase superfamily 1/2, ATP-binding domain
Helicase, C-terminal domain-like
P-loop containing nucleoside triphosphate hydrolase

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025