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MIRAGE
purinergic receptor P2X 2
Summary
- Gene Symbol
-
- P2RX2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- ATP-binding
- Alternative splicing
- Cell membrane
- Disease variant
- Disulfide bond
- Glycoprotein
- Hearing
- Ion transport
- Ligand-gated ion channel
- Non-syndromic deafness
- Proteomics identification
- Receptor
- Reference proteome
- Transmembrane helix
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to hypoxia | ||
| response to ischemia | ||
| detection of hypoxic conditions in blood by carotid body chemoreceptor signaling | ||
| neuromuscular synaptic transmission | ||
| neuromuscular junction development |
GO Hierarchy
biological process
biological regulation [inference]
regulation of biological process [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| apical plasma membrane | ||
| neuronal cell body |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| purinergic nucleotide receptor activity | ||
| extracellularly ATP-gated monoatomic cation channel activity | ||
| extracellularly ATP-gated monoatomic cation channel activity | ||
| extracellularly ATP-gated monoatomic cation channel activity | ||
| ATP binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- P2x purinoceptor
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| InterPro |
|---|
| P2X purinoreceptor extracellular domain superfamily |
| P2X purinoreceptor |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110567 | autosomal dominant nonsyndromic deafness 41 |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 22953 | Xenbase:XB-GENE-6043718 | ||
| 114115 | Xenbase:XB-GENE-6043718 | RATNO05323 | |
| 231602 | Xenbase:XB-GENE-6043718 | MOUSE44594 | |
| 387297 | Xenbase:XB-GENE-6043718 | ||
| 448781 | CANLF10206 | ||
| 527499 | BOVIN09306 | ||
| 751616 | FELCA28589 | ||
| 100061704 | HORSE41340 | ||
| 100080197 | ORNAN16301 | ||
| 100135591 | CAVPO25031 |
