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sortilin related VPS10 domain containing receptor 3

Summary

Gene Symbol

SORCS3

Organism

Homo sapiens (human)

External Links

NCBI Gene

22986

PubChem

22986

Alliance of Genome Resources

HGNC:16699

Annotation

Keyword

Glycoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UPU3
Q86XB2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
neuropeptide signaling pathway	NAS	11499680
postsynaptic modulation of chemical synaptic transmission	IEA
memory	IEA
learning	IEA
regulation of long-term synaptic depression	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

behavior [inference]

learning or memory [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic depression

postsynaptic modulation of chemical synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic depression

postsynaptic modulation of chemical synaptic transmission

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic depression

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	NAS	11499680
postsynaptic density membrane	IBA
glutamatergic synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
neuropeptide receptor activity	NAS	11499680

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

neuropeptide receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

neuropeptide receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sortilin

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
Sortilin, C-terminal
Sortilin, N-terminal
VPS10
WD40/YVTN repeat-like-containing domain superfamily

Ortholog

Displaying entries **11 - 20** of 68 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	854634		SGD:S000001435
Saccharomyces cerevisiae S288C	855802		SGD:S000005348
Equus caballus	100069497			HORSE16732
Ornithorhynchus anatinus	100081851			ORNAN07924
Taeniopygia guttata	100229522			TAEGU27387
Callithrix jacchus	100408455			CALJA07019
Pongo abelii	100452873	9601_0:002be8		PONAB01308
Xenopus tropicalis	100498333		Xenbase:XB-GENE-996343
Sus scrofa	100511162			PIGXX08472
Nomascus leucogenys	100607522			NOMLE26961