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Fas apoptotic inhibitory molecule 2

Summary

Gene Symbol

FAIM2

Organism

Homo sapiens (human)

External Links

NCBI Gene

23017

PubChem

23017

Alliance of Genome Resources

HGNC:17067

Annotation

Keyword

Alternative splicing
Apoptosis
Cell membrane
Glycoprotein
Postsynaptic cell membrane
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BWQ8	Fas apoptotic inhibitory molecule 2 Neural membrane protein 35 Transmembrane BAX inhibitor motif-containing protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
response to ischemia	IEA
regulation of neuron apoptotic process	IMP	17635665
cerebellar Purkinje cell layer development	ISS
apoptotic signaling pathway	IBA IEA
negative regulation of apoptotic signaling pathway

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

apoptotic signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation in hindbrain [inference]

cerebellar Purkinje cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar Purkinje cell differentiation

developmental process [inference]

anatomical structure development [inference]

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation in hindbrain [inference]

cerebellar Purkinje cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar Purkinje cell differentiation

response to stimulus [inference]

response to stress [inference]

response to ischemia

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of extrinsic apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway via death domain receptors [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of extrinsic apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway via death domain receptors [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of cellular process [inference]

signal transduction [inference]

apoptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of extrinsic apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway via death domain receptors [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

regulation of extrinsic apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway via death domain receptors [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane	IBA
postsynaptic membrane	IEA
Golgi apparatus	IBA
membrane raft	IDA	17635665
endoplasmic reticulum	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

membrane microdomain [inference]

membrane raft

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
calcium channel activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Bax inhibitor

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
Bax inhibitor 1-related

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 89 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	72393		MGI:1919643	MOUSE16372
Caenorhabditis elegans	179361		WB:WBGene00009580
Caenorhabditis elegans	179362		WB:WBGene00006470
Rattus norvegicus	246274		RGD:628744	RATNO38541
Xenopus laevis	444588		Xenbase:XB-GENE-6254875
Xenopus laevis	444684		Xenbase:XB-GENE-17331201
Pan troglodytes	451885	9598_0:003758		PANTR05920
Bos taurus	509790			BOVIN29227
Danio rerio	541391		ZFIN:ZDB-GENE-050320-88
Macaca mulatta	711559			MACMU05136