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MYC binding protein 2

Summary

Gene Symbol

MYCBP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

23077

PubChem

23077

Alliance of Genome Resources

HGNC:23386

Annotation

Keyword

3D-structure
Alternative splicing
Biological rhythms
Cell projection
Cytoskeleton
Disulfide bond
Guanine-nucleotide releasing factor
Nucleus
Phosphoprotein
Reference proteome
Repeat
Transferase
Ubl conjugation
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
O75592	Myc-binding protein 2 Protein associated with Myc

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
protein K48-linked ubiquitination	IDA	29997255
neuromuscular process	ISS
regulation of synaptic assembly at neuromuscular junction	IBA
regulation of cytoskeleton organization	IEA
negative regulation of protein catabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

protein K48-linked ubiquitination

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

motor neuron axon guidance [inference]

branchiomotor neuron axon guidance

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis

rhythmic process [inference]

circadian rhythm [inference]

circadian regulation of gene expression

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization

regulation of growth [inference]

regulation of developmental growth [inference]

regulation of synaptic assembly at neuromuscular junction

regulation of locomotion [inference]

regulation of chemotaxis [inference]

regulation of axon guidance

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of chemotaxis [inference]

regulation of axon guidance

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of synaptic assembly at neuromuscular junction

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axon guidance

regulation of organelle organization [inference]

regulation of cytoskeleton organization

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction

regulation of neuromuscular junction development [inference]

regulation of synaptic assembly at neuromuscular junction

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction

regulation of cellular localization [inference]

regulation of protein localization

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
membrane	HDA	19946888
intracellular membrane-bounded organelle	IDA
plasma membrane	IBA
nucleoplasm	IDA
axon	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	15161933 15778465 22357847 24136289 26496610 27278822 29293652 35271311 36931259
zinc ion binding	IDA	29643511
small GTPase binding	IDA	26304119
guanyl-nucleotide exchange factor activity	IDA	26304119
identical protein binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

E3 ubiquitin-protein ligase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
metal ion binding
regulation of synaptic assembly at neuromuscular junction

Displaying **all 2** entries
InterPro
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:936	brain disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	32429		FB:FBgn0030600
Mus musculus	105689		MGI:2179432	MOUSE12500
Caenorhabditis elegans	179259		WB:WBGene00004457
Caenorhabditis elegans	184118		WB:WBGene00017190
Rattus norvegicus	290447		RGD:1312048	RATNO09639
Danio rerio	368439		ZFIN:ZDB-GENE-030616-132	DANRE44745
Xenopus laevis	447587		Xenbase:XB-GENE-6253748
Pan troglodytes	452608	9598_0:0039d2		PANTR07920
Canis lupus familiaris	476952			CANLF08767
Bos taurus	534496			BOVIN03979

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements