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ELKS/RAB6-interacting/CAST family member 1

Summary

Gene Symbol

ERC1

Organism

Homo sapiens (human)

External Links

NCBI Gene

23085

PubChem

23085

Alliance of Genome Resources

HGNC:17072

Annotation

Keyword

Acetylation
Alternative splicing
Cell membrane
Cell projection
Chromosomal rearrangement
Coiled coil
Cytoskeleton
Direct protein sequencing
Golgi apparatus
Membrane
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome
Synapse

Proteins

Displaying **all 3** entries
UniProt	Protein Name
G8JLD3
Q8IUD2	Rab6-interacting protein 2
X6RLX0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
maintenance of presynaptic active zone structure	IBA
retrograde transport, endosome to Golgi	ISS
protein transport	IEA
regulation of DNA-templated transcription	IDA	15218148
regulation of transcription, DNA-templated	IDA	15218148

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

I-kappaB phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

I-kappaB phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

I-kappaB phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

I-kappaB phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

I-kappaB phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

I-kappaB phosphorylation

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

neuromuscular synaptic transmission

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

I-kappaB phosphorylation

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

synapse organization [inference]

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of presynaptic active zone structure

presynaptic active zone organization [inference]

maintenance of presynaptic active zone structure

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

neuromuscular synaptic transmission

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of biological quality [inference]

regulation of synaptic plasticity

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
presynaptic active zone cytoplasmic component	IBA
IkappaB kinase complex	IDA	15218148
anchoring junction	IEA
cytoskeleton of presynaptic active zone
Golgi membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

protein kinase complex [inference]

serine/threonine protein kinase complex [inference]

IkappaB kinase complex

cellular anatomical entity [inference]

cytoplasm

cell cortex [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

cytoplasmic region [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

microtubule organizing center [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

cytoskeleton [inference]

cortical cytoskeleton [inference]

cytoskeleton of presynaptic active zone

presynaptic cytoskeleton [inference]

cytoskeleton of presynaptic active zone

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

cytoskeleton [inference]

cortical cytoskeleton [inference]

cytoskeleton of presynaptic active zone

presynaptic cytoskeleton [inference]

cytoskeleton of presynaptic active zone

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12391317 12923177 16033967 22107844 27224062
structural constituent of presynaptic active zone	IBA
small GTPase binding	ISS
PDZ domain binding	ISS
cadherin binding	HDA	25468996

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of synapse [inference]

structural constituent of presynaptic active zone

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

protein domain specific binding [inference]

PDZ domain binding

cell adhesion molecule binding [inference]

cadherin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ELKS/RAB6-interacting/CAST family member 1

Functional Category

G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
neuromuscular synaptic transmission
regulation of synaptic plasticity
structural constituent of presynaptic active zone

Displaying 1 entry
InterPro
Active zone protein ELKS

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	35977		FB:FBgn0259246
Mus musculus	111173		MGI:2151013	MOUSE50767
Caenorhabditis elegans	177102		WB:WBGene00018330
Rattus norvegicus	266806		RGD:628733	RATNO30715
Pan troglodytes	451740	9598_0:003629		PANTR04817
Canis lupus familiaris	486753			CANLF11210
Bos taurus	519271			BOVIN30577
Danio rerio	548606		ZFIN:ZDB-GENE-091214-5
Danio rerio	560003			DANRE32608
Macaca mulatta	707010			MACMU04418

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements